Aims. To investigate whether L-citrulline (L-cit) supplementation represents a safe intervention in DN, and to assess the effects of L-cit on the inflammatory profile observed in DM. Methods. STZ-C57BL6 mice and rats received L-cit or vehicle supplemented in the drinking water (50 mg/kg/...
L-citrulline levels are also now used as biomarkers for certain diseases. One study found that low levels of citrulline signaled small bowel disease, intestinal failure, and bowel inflammation among 500 patients. Medical professionals have become increasingly interested in the benefits of L-citrulline ...
A detailed scientific examination of the evidence supporting claim that l-arginine/ l-citrulline supplementation improves vascular health.
l-Arginine, a substrate for NO synthase to generate NO, is mainly derived from protein catabolism (85%) or from l- citrulline by argininosuccinate synthase (ASS) and arginino- succinate lyase (ASL) (5). The transport of l-arginine is mainly mediated by the cationic amino acid ...
In contrast to l-arginine, l-citrulline escapes uptake in the liver and is present in the peripheral blood, and it is taken up in the kidney and converted to l-arginine, which is released into the circulatory system. Moreover, l-citrulline plays a key intermediate role in the urea cycle...
Arginine (Arg) is generated in the kidney by the conversion of circulating citrulline. The most important source for circulating citrulline is the metaboli... APJ Houdijk,PAMV Leeuwen,T Teerlink,... - 《Jpen Journal of Parenteral & Enteral Nutrition》 被引量: 167发表: 1994年 Postsurgery ente...
Nitric oxide is a potent vasodilator and inhibitor of platelet function; it exerts its effects via activation of soluble guanylate cyclase and subsequent formation of cyclic 3′–5′-guanosine monophosphate. In the kidney, activation of the endothelial L-arginine pathway is associated with increases ...
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L-Arginine, a substrate for NO synthase to generate NO, is mainly derived from protein catabolism (85%) or from L-citrulline by argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL) (5). The transport of L-arginine is mainly mediated by the cationic amino acid transporter (CAT)...