Specific and total activity data of kynurenine 3-hydroxylase in the submitochondrial fractions indicate that this enzyme is associated with the outer mitochondrial membrane, which is also confirmed by electron microscopy.doi:10.1016/0020-1790(81)90066-4Emmanuel Stratakis...
Synthesis and activity of enantiopure (S) (m-nitrobenzoyl) alanine, potent kynurenine-3-hydroxylase inhibitor. Biorg. Med. Chem Lett. 1995; 5 :1451–1454.Natalini B, Mattoli L, Pellicciari R, Carpenedo R, Chiarugi A & Moroni F (1995) Synthesis and activity of enantiopure (s)(m-...
Kynurenine 3-HydroxylaseEnzyme & Kinase Product No.RPH755Hu01Organism SpeciesHomo sapiens (Human) Same name, Different species. SourceProkaryotic expressionHostE.coliEndotoxin Level<1.0EU per 1µg (determined by the LAL method)Subcellular LocationMitochondrion...
in astrocytes via a side arm of the kynurenine metabolism. Therefore, due to the lack of kynurenine-hydroxylase (KYN-OHse), in case of hightryptophanbreakdown to KYN, KYNA may accumulate in astrocytes. A second key player in the metabolization of 3-HK are monocytic cells infiltrating the CNS...
Heidempergher F,Pevarello P,Pillan A, et al.Pyrrolo[3, 2-c]quinoline derivatives: a new class of kynurenine-3-hydroxylase inhibitors. Il Farmaco . 1999Heidempergher F, Pevarello P, Pillan A, Pinciroli V, Della Torre A, Speciale C, et al. Pyrrolo[3,2-c]quinoline derivatives: a ...
Localization and some properties of kynurenine-3-hydroxylase and kynurenine aminotransferase. Hayaishi,Okamoto - 《American Journal of Clinical Nutrition》 被引量: 3发表: 1971年 Characterization of rat brain kynurenine aminotransferases I and II The endogenous neuroprotectant kynurenic acid (KYNA) is ...
Kynurenine 3-hydroxylase and quinolinic acid phosphoribosyltransferase were unchanged, but the activities of kynureninase, 3-hydroxyanthranilate dioxygenase, and ... K Saito - 《American Journal of Physiology Renal Physiology》 被引量: 234发表: 2000年 Chlorogenic acid ameliorates brain damage and edema...
et al. Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase. Eur. J. Biochem. 267, 1092–1099 (2000). 17. Amaral, M. et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature 496, 382–385 (2013). 18. Smith, J. R., Jamie, J...
Costantino G, Mattoli L, Moroni F, Natalini B, Pellicciari R (1996) Kynurenine-3-hydroxylase asnd its selective inhibitors: molecular modelling studies. Adv Exp Med Biol 398:493–497Constantino G, Mattoli L, Moroni F, Natalini B, Pellicciari R (1996) kynurenine 3-hydroxylase and its...
Recombinant kynurenine-3-hydroxylase enzyme and process for its preparationThe present invention provides an isolated polynucleotide encoding for the kynurenine-3-hydrolase (Kyn-3-OHase) and methods of transiently expressing thereof.Simona Magagnin