KRAS 基因突变EXON 2 MUTATION Allele Registry ID:别名: ClinVar ID: 外显子2突变与非小细胞肺癌和结直肠癌中对表皮生长因子受体抑制剂的应答率降低或耐药性有关。NCCN大肠癌指南中建议,靶向治疗西妥昔单抗和帕尼图单抗只能用于野生型KRA。 Exon 2 mutations have been associated with reduced response rates or...
近日,《肿瘤学年鉴》(Annals Of Oncology)发表了题为:Different prognostic values ofKRASexon 2 submutations andBRAF V600Emutation in microsatellite stable (MSS) and unstable (MSI) stage III colon cancer: an ACCENT/IDE...
Krzysztof R,Bogdan Z,Wojciech JO,et al.Impact of specific KRAS mutation in exon 2 on clinical outcome of chemotherapy-and radiotherapy-treated colorectal adenocarcinoma patients[J].Mol Diagn Ther,2014,18(5):559-566.Impact of Specific KRAS Mutation in Exon 2 on Clinical Outcome of Chemotherapy-...
EXON 2 MUTATION Q61H G13C AMPLIFICATION Q61P Q61L Q61FS G13V Q61K Q61R Q61E G13R G13S ACTIVATING MUTATION RS61764370 A146P A146V Q61 G13 Q22* WILD TYPE K117N A59T KRAS 基因突变 G13 Allele Registry ID:别名:GLY13 ClinVar ID:12580,45123,12593,375968,375967,45124,163769,45125 ...
此前,厚朴方舟曾帮助一位存在KRAS Exon-2突变的肺癌患者王先生预约日本医科大学附属医院癌症中心教授——久保田馨进行远程会诊。会诊过程中,久保田馨教授详细评估了王先生的病情,并确定了后续的治疗方案。推荐阅读:【厚朴案例】KRAS靶点新药上市,选择...
Fig. 1. miRNAs mediated down-regulation of mutationally activated oncogenic KRAS and its downstream signaling pathways in PDAC. KRAS*, mutational activation of KRAS; RAF, Raf/mil family of serine/threonine protein kinases; MEK, mitogen activated protein kinase; ERK, extracellular signal-regulated kin...
In 9 (60%) patients, at least one sample was positive for the presence of a KRAS exon 2 mutation. In 11 out of 28 samples (39.2%) with detectable CTCs a KRAS mutation was detected; the corresponding percentages for baseline and on progression samples were 27% and 37.5%, respectively. ...
(exons 2, 3 and 4), NRAS (exons 2, 3 and 4), PIK3CA (exon 20) and BRAF (exon 15) genes using reverse transcriptase-polymerase chain reaction (RT-PCR) and Sanger sequencing in a large cohort of 1,110 Chinese CRC patients who underwent surgical resection at one of three major ...
(exons 2, 3 and 4), NRAS (exons 2, 3 and 4), PIK3CA (exon 20) and BRAF (exon 15) genes using reverse transcriptase-polymerase chain reaction (RT-PCR) and Sanger sequencing in a large cohort of 1,110 Chinese CRC patients who underwent surgical resection at one of three major ...
Here we show that cells harboring KRAS Q61H are uniquely resistant to SHP2i, and investigate the underlying mechanisms using biophysics, molecular dynamics, and cell-based approaches. Q61H mutation impairs intrinsic and GAP-mediated GTP hydrolysis, and impedes activation by SOS1, but does not alter...