There is substantial experience attempting to treat KRAS-mutated lung adenocarcinoma with the use of RAS/RAF multikinase inhibitors as well as inhibitors of both upstream and downstream proteins important in RAS signaling. We review the disappointing results from these clinical trials in lung cancer. ...
Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is const...
Rona Yaeger, et al, Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer, Cancer Discov (2024).
microsatellite-stable, KRAS-mutated colon cancer patient after treatment with sintilimab and bevacizumab and platinum-based chemotherapy: a case report and literature review. Front Immunol. 2024 Mar 28;15:1354613. doi: 10.33...
The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer Mengyu Xie Long Zhang Nasha Zhang Article7 Oct 2023 Oncogene S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer K. Srivastava K. E. Lines T. Cr...
https://u.wechat.com/MFyT_vWQMAlv6-sjlOt1LHs (二维码自动识别) 参考文献: Rona Yaeger, et al, Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer, Cancer Discov (2024).
参考文献: J. Baptiste Oudart, S. et al., STK11/ LKB1 alterations worsen the poor prognosis of KRAS mutated early-stage non-squamous non-small cell lung carcinoma, results based on the phase 2 IFCT TASTE trial, Lung Cancer (2024). 发布于 2024-03-01 18:04・IP 属地北京 ...
参考文献:https://www.mdanderson.org/cancerwise/targeting-the-kras-mutation-for-more-effective-cancer-treatment.h00-159458478.htmlhttps://patientworthy.com/2023/05/17/kras-mutated-colorectal-cancer-tumors-treatment-difficulties/https://www.nejm.org/doi/full/10.1056/NEJMc2208623https://www.nature....
[3]Wouter W. Mellema, et al.Comparison of clinical outcome after first-line platinum-based chemotherapy in different types of KRAS mutated advanced non-small-cell lung cancer.Lung Cancer. 2015 Nov;90(2):249-54. [4]Anna Ketal.Survival outcome according to KRAS mutation status in newly diagnos...
https://www.mdanderson.org/cancerwise/targeting-the-kras-mutation-for-more-effective-cancer-treatment.h00-159458478.html https://patientworthy.com/2023/05/17/kras-mutated-colorectal-cancer-tumors-treatment-difficulties/ https://www.nejm.org/doi/full/10.1056/NEJMc2208623https://www.nature.com/art...