Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C. N Engl J Med. 2023;388(1):44-54. 5. Pant S, Wainberg ZA, Weekes CD, et al. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal canc...
Pts with KRAS G12C–mutated mCRC who had not received any prior systemic Tx for metastatic disease were enrolled at 17 global sites (between Jul 2021 and Mar 2024) and received the recommended phase 2 dose of soto (96...
[3]Near-Complete Response to Combined Pembrolizumab and Platinum-Doublet in a Patient With STK11/KRAS Mutated Advanced Lung Adenocarcinoma. Clin Lung Cancer 2022 03;23(2) [4]An advanced non-small cell lung cancer patient with and mutations, and PD-L1 positive, benefited from immunotherapy: a ...
今天就以胰腺癌，肺癌，肠癌为例，和大家一起了解KRAS的奥秘。胰腺癌 2018年蓉蓉（化名）不幸被确诊为胰腺癌，在这期间，她进行了新辅助化疗，手术等，治疗完成后蓉蓉(化名)的病情也有所好转。但不幸的是，在一年之后癌症又复发了，医生通过细针抽取右肺下叶的一个增大的结节证明了肺转移的存在。《圣经》说“上...
8, Ziming Li, et al. Garsorasib in patients with KRASG12C-mutated non-small-cell lung cancer in China: an open-label, multicentre, single-arm, phase 2 trial. The Lancet Respiratory Medicine, 2024. https://doi.org/10.1016/S2213-2600(24)00110-3 9. 公司官网发布信息（官网或财报）。
https://patientworthy.com/2023/05/17/kras-mutated-colorectal-cancer-tumors-treatment-difficulties/ https://www.nejm.org/doi/full/10.1056/NEJMc2208623https://www.nature.com/articles/s41698-021-00237-5
https://www.prnewswire.com/news-releases/fda-approves-lumakras-sotorasib-the-first-and-only-targeted-treatment-for-patients-with-kras-g12c-mutated-locally-advanced-or-metastatic-non-small-cell-lung-cancer-301301808.html [3]U.S. Food and Drug Administration (FDA) Accepts Mirati Therapeutics' New...
[2]Gadgeel SM, Jänne PA, Spira AI等人。‘KRYSTAL-1: two-year follow-up of adagrasib (MRTX849) monotherapy in patients with advanced/metastatic KRASG12C-mutated NSCLC’，发表于国际肺癌研究协会 2023 年世界肺癌大会；2023年9月9日至12日；新加坡。[3]Abstract 99O_PR ‘KRYSTAL-1: Activity ...
[3]Wouter W. Mellema, et al.Comparison of clinical outcome after first-line platinum-based chemotherapy in different types of KRAS mutated advanced non-small-cell lung cancer.Lung Cancer. 2015 Nov;90(2):249-54. [4]Anna Ketal.Survival outcome according to KRAS mutation status in newly diagnos...
[2]Gadgeel SM, Jänne PA, Spira AI等人。‘KRYSTAL-1: two-year follow-up of adagrasib (MRTX849) monotherapy in patients with advanced/metastatic KRASG12C-mutated NSCLC’,发表于国际肺癌研究协会 2023 年世界肺癌大会;2023年9月9日至12日;新加坡。