Lito P, Solomon M, Li L S, et al. Allele-specific inhibitors inactivatemutant KRAS G12C by a trapping mechanism[J]. Science, 2016,351(6273): 604-608. Janes M R, Zhang J C, Li L S, et al. Targeting KRAS mutant cancerswi...
Using a chronic jetlag model, we investigated the impact of clock misalignment on pancreas cancer initiation in mice harboring a pancreas-specific activated Kras mutation. We found that chronic jetlag accelerated the development of pancreatic cancer precursor lesions, with a concomitant increase in ...
The accumulated FAs in the TME have been found to cause the dysfunction of immune cells in KRAS-mutant mice model[86]. In the infiltrated cytotoxic CD8+ T cells, the long-chain fatty acids are unbreakable and can result in a reduction of very-long-chain acyl-CoA dehydrogenase and lipid ...
In conclusion, in this study, we provide evidence that ectopic expression of oncogenic mutant K-Ras in pancreatic ducts generates early and late PanIN as well as PDAC. This Ras rheostat model provides evidence that AKT signaling is an important early driver of invasive ductal derived PDAC....
Current inhibitor strategies targeting mutant KRAS Lipid-based nanocarriers used in gene delivery Application of gene therapy targeting mutant KRAS in cancers Conclusions Data availability References Funding Author information Ethics declarations Additional information Rights and permissions About this article Adver...
KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiquitin-like co
. One of the limitations of this latter model is the lack of development ofmetastasesindicating that additional lesions are required for these tumors to progress. Further experiments exploring the biology of mutant EGFR are likely to reveal that additional changes are important for metastatic ...
这些并发的遗传病变也与肺肿瘤相关,这些肺肿瘤的特征是在肿瘤微环境中具有不同的免疫细胞动力学。Trp53L / L (KP)转基因小鼠,并发p53缺陷呈现KP肿瘤更chemoresistant,相比之下,要么喀斯特单独或与并发Lkb1 Kras突变。考虑到高速率KRAS-...
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations. Cancer Res. 2022;82(19):3435–48. https://doi.org/10.1158/0008-5472.CAN-22-0325. Article CAS PubMed PubMed Central Google Scholar Download references...
Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, the role of FA in LC tumorigenesis is still not sufficiently characterized. Here, we show that KMLC has a specific lipid profile, with high triacylglycerides and phosphatidylcholine...