KRAS knockdown resulted in unique methylation changes with limited overlap between each cell line. In KRAS-mutant Pa16C pancreatic cancer cells, while KRAS knockdown resulted in over 8,000 differentially methylated (DM) CpGs, treatment with the ERK1/2-selective inhibitor SCH772984 showed less than ...
MRTX849 selectively targets the mutant cysteine 12 of KRAS in GDP, which is present in the induction-switch II pocket of KRAS (G12C), thereby locking it into an inactive GDP-binding state and inhibiting the RAS/MAP kinase pathway. In KRAS (G12C) positive cell lines and patient-derived ...
first-lineimmune checkpoint inhibitors (ICIs)anti-vascular therapychemotherapyKRAS mutations are common in non-small cell lung cancer (NSCLC) and are associated with patient prognosis; however, targeting KRAS has faced various difficulties. Currently, immunotherapy, chemotherapy, and chemoimmunotherapy play...
4.Ferrer I,Zugazagoitia J,Herbertz S,et al.KRAS-mutant non-small cell lung cancer:from biology to therapy[J].Lung Cancer,2018,124:53-64. 5.Skoulidis F,Heymach JV.Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy[J].Nat Rev Cancer,2019,19(9):495-509...
[16]Ferdinandos Skoulidis,etal.STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarc.CANCER DISCOVERY [17]Rebecca Suk Heist,et al.Impact of STK11 mutation on first-line immune checkpoint inhibitor (ICI) outcomes in a real-world KRAS G12C mutant lung adenocarcinoma...
cell lines [29] and, in pancreatic cancer, increased YAP could replace dependence on KRAS activity [30,31]. Here we show that the forced expression of active YAP in MDA-MB-231 cells (a highly aggressive human breast cancer cell line that carries a mutant KRAS gene) also promoted their ...
今天,我们特别关注美国康奈尔医学院陈水冰教授、Todd Evans教授团队于2023年12月26日发表在《Cell Stem Cell》(IF:23.9)的经典研究——A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS,该研究通过CRISPR/Cas9的技术构建等基因突变胰腺类器官,利用胰腺类器官进行高通量药物筛选研究,...
KRAS mutant-A375 Isogenic Cell Line推荐供应商 我要询价 ATCC(美国模式培养物集存库) 联系电话:40-15317324578 17301805756 电子邮件:ATCC@qq.com CB指数:58 网址:http://www.atcc.org 相关信息:产品目录(3342)用户评价 英文名称:KRAS mutant-A375 Isogenic Cell Line ...
Cell lines and immunoblotting The KRAS mutant human cell lines HCC44, NCI-H23, NCI-H2122, SW1573 and NCI-H1373 were purchased from ATCC. H1792 is a gift from Professor Liu Xiangguo of Shandong University and HCC44-Luc is a gift from Professor Lu Weiyue of Fudan University. HCC44 were...
Treatment outcomes and clinical characteristics of patients with KRAS-G12C-mutant non-small cell lung cancer. Clin Cancer Res 2021;27:2209-15. DOI PubMed 14. Sun L, Hsu M, Cohen RB, Langer CJ, Mamtani R, Aggarwal C. Association between KRAS variant status and outcomes with first-line ...