4.Lee JW, Komar CA, Bengsch F, Graham K, Beatty GL. GeneticallyEngineered Mouse Models of Pancreatic Cancer: The KPC Model(LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre), Its Variants, andTheir Application in Immuno-oncology Drug Discovery. Curr...
pancreatic cancer cell sources of subcutaneous/orthotopic transplantation tumor and their correlation techniques [4,5], patient-derived subcutaneous/orthotopic xenografts (PDXs) and their correlation techniques [6] and various genetically engineered mouse models (GEMMs) and organoid models of pancreatic cance...
TNBC cells and shared between mouse (4T1 cell line) and human (MDA-MB-231 cell line (fold-change of 1.5 and adjusted p < 0.1) identified 148 genes (Table S3). To evaluate whether a biological process hallmark could be associated with the loss of CD95 in these analyses, we performed ...
Let CellEDIT accelerate your research by creating your custom engineered KPC cell line. We’ll handle the CRISPR editing so you can run your experiment faster and finish your project sooner.
Baseline immune profiling and IHC staining showed enrichment of myeloid-derived suppressor cells and macrophages in the TME, obvious fibrosis, and angiogenesis in line with parental KPC MuPrime model data.Conclusions: We have established and characterized a bioluminescent orthotopic KPC mouse model mPA...
cell line was generated by culturing pancreatic tumor tissue from the genetically modified C57BL/6J-KPC mouse, a well-validated and clinically relevant model of PDAC. It develops many key features observed in human PDAC such as pancreatic intraepithelial neoplasia, metastasis to the liver and lungs...