Collated experimental evidence of estimated unbound brain drug concentration (right panel) better correlating with effect than measured total brain concentration (left panel) across series of molecules. (A) Correlation betweenin vitropotency (Ki) and brain EC50 for antinociception in mice (47). (B)...
Ideally, a physiological tracer should be used to follow the uptake, transpo... RD Spence,PJH Sharpe 被引量: 1发表: 1991年 A Conceptual Study on Biotope Mapping in the City 3. It is desirable to use a comprehensive and long-term oriented approach rather than to use a partial short-term...