Heptelidic acid (Koningic acid) 是一种倍半萜类抗生素 (antibiotic)。Heptelidic acid 通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。Koningic acid (KA) 是一种特异性 GAPDH 抑制剂,IC50 为90 μM。 Heptelidic acid Chemical Structure CAS No. : 57710-57-3 规格是否有货 1 mg 询价 * Plea...
七萜酸 Heptelidic acid (Koningic acid) 是由真菌T. koningii产生的一种邻半萜内酯,对厌氧菌如拟杆菌具有抗菌活性。它作为一种不可逆的GAPDH抑制剂,与酶活性位点的半胱氨酸-149残基结合。七萜酸是一种倍半萜类抗生素 (antibiotic)。七萜酸通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。七萜酸是一种特异...
A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in large quantities by fermentation, thus allowing (i...
We found that koningic acid (KA), an inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), selectively kills high-glycolytic cells through glucose-dependent active ATP deprivation. Out of seven tumor cell lines tested, growth of six cell lines, which had high glycolytic capacity, was ...
Koningic acidThyroid cancerGlycolysis abilityAntineoplastic activityExtracellular acidification rateATP deprivationOur data demonstrate that KA kills thyroid cancer cell lines by inhibiting their glycolysis ability, the MAPK/ERK pathway and the Bcl-2 level and suggest that KA has potential clinical value in...