七萜酸 Heptelidic acid (Koningic acid) 是由真菌T. koningii产生的一种邻半萜内酯,对厌氧菌如拟杆菌具有抗菌活性。它作为一种不可逆的GAPDH抑制剂,与酶活性位点的半胱氨酸-149残基结合。七萜酸是一种倍半萜类抗生素 (antibiotic)。七萜酸通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。七萜酸是一种特异...
Heptelidic acid (Koningic acid) 是一种倍半萜类抗生素 (antibiotic)。Heptelidic acid 通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。Koningic acid (KA) 是一种特异性 GAPDH 抑制剂,IC50 为90 μM。 Heptelidic acid Chemical Structure CAS No. : 57710-57-3 规格是否有货 1 mg 询价 * Plea...
UNII号 6H8EDV2NKQ 化学名 KONINGIC ACID 分子式 C15H20O5 CAS号 57710-57-3 结构式图片 SMILES [H][C@]12C=C(COC(=O)[C@]1([H])[C@]3(CO3)CC[C@@H]2C(C)C)C(O)=O INCHIKEY JESMSCGUTIEROV-RTWAVKEYSA-N 扩展信息 ...
Dihydroguaiaretic acid 土木香内酯 42895-57-8 松茋 Coumalic acid 24967-93-9 Monomyristin 23513-14-6 野百合碱 100665-43-8 次黄嘌呤 Gentisin 生长激素释放肽-6 岩大戟内酯B 1-咖啡酰奎宁酸 84650-60-2 松脂素-4-O-葡萄糖苷 66648-43-9 ...
NEW MATERIAL:Koningic acid having the following characteristics: elemental analysis, C 60.29%, H 6.26%, O 33.45%; molecular weight, 280; molecular formula, C15H20O5; melting point, 46-48.5 deg.C; specific rotation, [alpha]D<25>=+24.1 deg. (C=1 ethanol); solubility, soluble in methanol...
NEW MATERIAL:Koningic acid having the following characteristics: elemental analysis, C 60.29%, H 6.26%, O 33.45%; molecular weight, 280; molecular formula, C15H20O5; melting point, 46-48.5 deg.C; specific rotation, [alpha]D<25>=+24.1 deg. (C=1 ethanol); solubility, soluble in methanol...
A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in large quantities by fermentation, thus allowing (i...
Koningic acidThyroid cancerGlycolysis abilityAntineoplastic activityExtracellular acidification rateATP deprivationOur data demonstrate that KA kills thyroid cancer cell lines by inhibiting their glycolysis ability, the MAPK/ERK pathway and the Bcl-2 level and suggest that KA has potential clinical value in...
Cloning of two isozymes of Trichoderma koningii glyceraldehyde-3-phosphate dehydrogenase with different sensitivity to koningic acid-i0 -I 1 ~ATCCTTCTT CATCCTTTTC CCTACAGCCT ~ATCTCCCTC AAGCACTGTG ~TACTATTGT ~GCATATTGA ~CCATACAAA ~ATCTTCTCT ~TTGOCAAA~ 2 CAAG CATCTTATTT TGCCTCGTAT CAACTTC...