Figure 37-8 The posterior cruciate ligament is an important ligament because of its cross-sectional area, tensile strength, and location in the central axis of the knee joint. (From Scott WN: Ligament and extensor mechanism injuries of the knee: diagnosis and treatment, St Louis, 1991, Mosby...
(3) Description of CBT intervention: (including duration, frequency, the background of implementers, and method of implementation); (3) Primary outcome measures: Pain intensity (VAS score, NRS score); Secondary outcome measures: Knee joint function (KSS score, HSS score), Psychological status (...
The retention amount of 125I-labeled CB particles in the joint (a). The experimental data were afterwards analyzed using the one-phase decay model (b) (n = 8). Calculated data are shown in (b), revealing the clearance rate. (c) A schematic diagram illustrating the passage and ...
MSCs can also promote joint tissue repair by inhibiting apoptosis and promoting angiogenesis. In conclusion, MSCs play a role in the treatment of KOA through multiple mechanisms, which can promote cartilage repair and regeneration, inhibit inflammatory response, regulate the immune system and promote ...
As a common degenerative disorder, osteoarthritis (OA) encompasses several physiological and biomechanical variations in the joint, including articular reconstruction, chondral deterioration, and formative hyperostosis, resulting in symptomatic manifestations [1]. Although it incurs substantial social and individu...
MSCs are attractive therapeutic candidates for OA due to their multimodal mechanisms of action, including their immunomodulatory properties. MSCs modulate the inflammatory cytokine milieu and immune cell responses in the joint via the release of secreted paracrine factors and extracellular vesicles (EVs) ...
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural, inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific manner. This complexity has contributed to refractory responses to various tre
Whenever the knee joint cannot be salvaged, knee disarticulation should be strongly considered as the next best level for prosthetic function, rather than transfemoral amputation. It is a simpler, less shocking procedure with minimal blood loss and rapid postoperative recovery because virtually no muscl...
At which site are the earliest bony changes detected radiographically: in the subchondral region or at the articular margins of the synovial joint? The difficulty in determining the sequence of changes at these sites lies in not being able to identify the start of the disease or know the initi...
Such testing has been done on cartilage explants and osteochondral cores at the tissue scale, as well at the joint-scale using pendulum testing and with a CPM device. 5.515.5.2.2 Viscosupplementation Viscosupplementation of SF with exogenous preparations, typically HA-derived molecules, is used ...