Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol. 2007;81:945–53.Bengsch B, Spangenberg HC, Kersting N, Neumann- Haefelin C, Panther E, von Weizsacker ...
than KLRG1−CD127+CD8+T-cells. Therefore, the modulation of CD8+T-cell differentiation in FL by PI3K inhibitors may promote a more effective antitumor immune response and thus improve the clinical prognosis of lymphoma patients [121]. KLRG1 may also be a marker for monitoring antitumor response...
在急性感染期间,抗原特异性CD8 T细胞扩增并分化表达为KLRG1highCD127low的CD8记忆前体效应细胞(MPEC)以及表达为KLRG1lowCD127high的短寿效应细胞(SLEC)。7CD127是白细胞介素7的受体,可通过增加抗凋亡因子表达来决定细胞的寿命;因此,MPEC的CD127表达水平高于SLEC。8相应图例显示了使用针对KLRG1和CD127的荧光偶联抗体在...
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whereas NAPC increased the infiltration of CD20+B cells, CD4+T cells, CD4+CD127+T cells, CD8+T cells, CD8+CD127+and CD8+KLRG1+T cells. Synergistic increase in B and T cells promotes favorable therapeutic response after NAPC. Spatial distribution analysis discovered that CD8+T cells and th...
these two proteins may interact to inhibit KLRG1+CD8+T-cell effector function, leading to immune dysfunction in CLL patients [117]. In patients with FL, CD8+T-cells lose their proliferative capacity after differentiating into KLRG1+CD127−CD8+T-cells, which have a greater capacity to produce...
KLRG1 as a Tool for Understanding Acute Immune Response During acute infection, antigen-specific CD8 T cells expand and differentiate CD8 memory precursor effector cells (MPECs), which express KLRG1highCD127low, and short-lived effector cells (SLECs), which express KLRG1lowCD127high.7CD127, the...
NAC resulted in an increase only of CD20(+) B cells, whereas NAPC increased the infiltration of CD20(+) B cells, CD4(+) T cells, CD4(+)CD127(+) T cells, CD8(+) T cells, CD8(+)CD127(+) and CD8(+)KLRG1(+) T cells. Synergistic increase in B and T cells promotes favorable ...
However, the dramatic reduction in KLRG1hi cells caused by loss of Id2 remained in the absence of Bim, such that Id2/Bim double-deficient cells form an exclusively KLRG1lo CD127hi memory precursor population. Thus we describe a role for Id2 in both the survival and differentiation of ...