Klebsiella pneumoniae is a common cause of hospital- and community-acquired infection and can readily acquire multiple antimicrobial resistance determinants leading to poor health outcomes. We define the contemporary burden of disease, risk factors for antimicrobial resistance, and poor health outcomes for...
Impact of the ST101 clone on fatality among patients with colistin-resistant Klebsiella pneumoniae infection. J Antimicrob Chemother. 2018;73(5):1235–41. Article CAS PubMed Google Scholar Roe CC, et al. Diversity, virulence, and antimicrobial resistance in isolates from the newly emerging ...
Extrahepatic metastatic infection is a devastating complication for KP-PLA patients. Metastatic KP-PLA patients were in relatively severe conditions and more often admitted to ICU, but even so, about 20% patients still died eventually. To eliminate the effect of variation in demographic composition of...
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Clinical and Molecular Characterizations of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infection in a Chinese Hospital. Microbiol. Spectr. 2022, 10, e0169022. [CrossRef] 42. Wyres, K.L.; Nguyen, T.N.T.; Lam, M.M.C.; Judd, L.M.; van Vinh Chau, N.; Dance, D.A....
The final volume was 1.0 mL and the multiplicity of infection was 10:1. Each tube was incubated in a shaking water bath at 37 ◦C and transferred to an ice bath at a designated time point. A FACScan emitting an argon laser beam at 488 nm was used to detect FITC fluorescence. A ...
Multidrug-resistant CTX-M-15-positive Klebsiella pneumoniae ST307 causing urinary tract infection in a dog in Brazil. J. Glob. Antimicrob. Resist. 2019, 19, 96–97. [Google Scholar] [CrossRef] Carvalho, I.; Alonso, C.A.; Silva, V.; Pimenta, P.; Cunha, R.; Martins, C.; Igrejas,...
The culture was then centrifuged at 4000× g for 10 min at 4 ◦C, and suspended in a 1/10 volume of SM buffer; a 0.1 mL of bacteriophage was then added to 0.9 mL of the bacterial cell suspension to achieve a Multiplicity of Infection (MOI) of 0.01. Phages were allowed to absorb...
International Journal of Infectious Diseases Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 causing an outbreak in a tertiary care hospital in Riyadh, Saudi Ara. Int. J. Infect. Dis. 2014, 28, 186–192....
In addition to direct killing of pathogens, they can also help recruit immune cells to the site of infection and neutralize the pro-inflammatory effects of endotoxins. They have multimodal killing mechanisms, involving interaction with bacterial components different to those targeted by conventional ...