The methods and compositions target the activity of the human kinesin-like protein KIF18A (and the KIF18A ortholog, KLP67A) and homologs thereof, and a gene encoding KIF18A or a homologous or orthologous gene. KIF18A and KLP67A are kinesin superfamily (KIF) proteins. Members of the KIF ...
The methods and compositions target the activity of the human kinesin-like protein KIF18A (and the KIF18A ortholog, KLP67A) and homologs thereof, and a gene encoding KIF18A or a homologous or orthologous gene. KIF18A and KLP67A are kinesin superfamily (KIF) proteins. Members of the KIF ...
AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.
Aggressive cancers like high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC) have a high frequency of CIN and TP53 mutations. Here, we show that inhibitors of the KIF18A motor protein activate the mitotic checkpoint and selectively kill chromosomally unstable cancer ...
英文名称:Human Kinesin-like protein KIF18A (KIF18A) ELISA Kit 北京华夏远洋科技有限公司 联系电话:010-62898668 15311620006 电子邮件:huaxiabio@163.com CB指数:58 网址:www.hxbio.net 相关信息:产品目录(6122) 用户评价 英文名称:Human Kinesin-like protein KIF18A (KIF18A) ELISA Kit 上海瑶韵生物科技...
Thus, Xl_Kif18A is the functional orthologue of human Kif18A whose activity is essential for the correct function of meiotic spindles in Xenopus oocytes. 展开 关键词: Kif18A Kinesin-8 Meiosis Spindle structure Xenopus laevis DOI: 10.1242/bio.023952 被引量: 12 ...
A database search for potential homologs of the Kin I family in the entire genome sequence (The Sanger Centre, Hixton, UK) revealed that fission yeast possesses two members, which are named Klp5 and Klp6 (kinesin-like protein). Both proteins show 38% identity to human Kin I/MCAK or Xen...
During vertebrate mitosis, the centromere-associated kinesin CENP-E (centromere protein E) transports misaligned chromosomes to the plus ends of spindle microtubules. Subsequently, the kinetochores that form at the centromeres establish stable associatio
The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A J. Cell Sci., 109 (1996), pp. 961-969 CrossrefView in ScopusGoogle Scholar 14 B.A. Weaver, Z.Q. Bonday, F.R. Putkey, G.J. Kops, A.D. Silk, D.W. Cleveland Centr...
like microcephaly-associated protein (ASPM) also negatively modulates KIF11 expression, and the regulatory effects of the ASPM/KIF11 signaling on tumor proliferation, invasion, and migration may be linked to WNT/β-catenin signaling transduction. (B) Kinesin-6 family: For KIF20A, identified as an...