The reasons why patients with leukemia fail to respond to chemotherapy, in which the nucleoside analogues play an important role, are largely unknown. Deoxyribonucleoside kinases catalyze the first step in the intracellular phosphorylati... F Albertioni,N Bayat,K Karlsson,... - 《Cancer Research》...
Kinase enzymes catalyze protein phosphorylation by transferring the γ-phosphoryl of ATP onto substrate hydroxyl groups (Fig. 1B) (1, 2, 3, 5). Kinases are generally classified by their amino acid specificity, with Ser/Thr kinases modifying Ser and Thr residues, Tyr kinases acting on Tyr, an...
Sandrini M & Piskur J (2005) Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction. Trends Biochem Sci 30, 225-228.Sandrini, M.P. and Piškur, J., 2005. Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction. Trends in Biochemical Sciences, 30(5)...
Protein kinasesare the largest enzyme superfamily involved in cell signal transduction. They are encoded by approximately 2% of eukaryotic genes and more than 500 protein kinases are predicted based on the human genome sequencing[1]. Protein kinases catalyze protein phosphorylation, i.e., the transfer...
Another interesting kinase independent target of ERK2 is PolyADP-ribose polymerase 1 (PARP-1), where no kinase activity of ERK is required. PARPs catalyze the posttranslational modification of nuclear proteins by polyADP-ribosylation. Usually, the catalytic activity of PARP-1 is stimulated by DNA...
Guanylate cyclases (GCs) are enzymes that catalyze the reaction to produce cyclic GMP (cGMP), a key signaling molecule in eukaryotes. Nevertheless, systemic identification and functional analysis of GCs in crop plant species have not yet been conducted. In this study, we systematically identified ...
Mammalian and Human IP3Ks catalyze a single reaction that specifically phosphorylate inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4) [12,13,14,15]. The mammalian IP6Ks and yeast Kcs1 phosphorylate the C5 position of inositol hexakisphosphate (IP6) and 1-Ins...
(Table1). There are 12 molecules of drFam20C in the crystal asymmetric unit, which organizes into six pairs of homodimers similar in overall structure to the Fam20A−Fam20C heterodimer (Fig.3b, Supplementary Fig.4A). All the residues that participate in the drFam20C dimer interface are...
Protein kinases play a predominant regulatory role in nearly every aspect of cell biology [1]. The human protein kinase family consists of 518 genes, which correspond to about 1.7% of the genome, thereby making it one of the largest gene families [2]. Protein kinases catalyze the reaction il...
3). Although these proteins are unrelated and catalyze very different reactions, ATP is a common substrate, consistent with the reactivity of the probe (supplemental Table S5). Protein structures of homologs of PGK1, ATPB, CAC2, and ribose-phosphate pyrophosphokinase 4 contain the labeled Lys ...