Pathology revealed a JXG-like histopathology with a rare KIF5B-ALK fusion gene. This is the first isolated ALK-positive lesion to be reported in this location. The discovery of the new ALK-positive subclass of histiocytosis has opened the door for targeted monoclonal ALK inhibition....
The clinicopathological spectrum of ALK-positive histiocytosis is broader than originally described, and this entity is characterized by frequent presence of KIF5B-ALK gene fusion. We recommend that every unusual histiocytic proliferative disorder, especially disseminated lesions, be tested for ALK expression...
HistiocyticALK-positive histiocytosisKIF5B-ALKfusionCentral nervous systemActa Neuropathologica -doi:10.1007/s00401-019-02027-7Calixto-Hope G. LucasAhmed GilaniDavid A. SolomonXiayuan LiangArie PerrySpringer NatureActa Neuropathologica
Disseminated ALK-positive histiocytosis with KIF5B-ALK fusion in an adultdoi:10.1080/10428194.2020.1861273Lianqun QiuSteven P. WeitzmanLoretta J. NastoupilMichelle D. WilliamsFrancisco VegaLeukemia and Lymphoma
(ALK), including KIF5B-ALK fusion, have been identified in histiocytic neoplasms.3,4 We present the case of a patient with CNS lesions causing neurological disorders, in whom systemic JXG with KIF5B-ALKfusion was detected by next-generation sequencing (NGS) panel-based comprehensive genome ...
ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion.doi:10.1038/S41379-018-0168-6Kenneth Tou En ChangAmos Zhi En TayChik Hong KuickHuiyi ChenElizabeth AlgarNadine TaubenheimJanine Campbell
It was recently reported in nonsmall cell lung cancer (NSCLC) that the fusion protein encoded by echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) fusion gene conferred oncogenic properties. The objective of the current study was to identify other possible ALK fusion genes in NSCLC....