Pathology revealed a JXG-like histopathology with a rare KIF5B-ALK fusion gene. This is the first isolated ALK-positive lesion to be reported in this location. The discovery of the new ALK-positive subclass of histiocytosis has opened the door for targeted monoclonal ALK inhibition....
其存在与其他已知的基因改变如EGFR、 K—Ras、ALK等相互排斥,提示KIF5B—RET是一种新的致癌驱动突变,有可能成为qH,细胞肺癌个体化诊断与治疗的一个分子 靶点。 【关键词】 KIF5B—RET;非小细胞肺癌;融合基因 中图分类号 :R734.2 文献标识码:A 文章编号:1009—0460(2013)02—0183—04 KIF5B-RET fusiongeneand...
ZytoLight SPEC ALK/2q11 Dual Color Probe ZytoLight SPEC ALK/EML4 TriCheck Probe ZytoLight SPEC Angelman Dual Color Probe ZytoLight SPEC BCL2 Dual Color Break Apart Probe ZytoLight SPEC BCL2/CEN 18 Dual Color Probe ZytoLight SPEC BCL2/IGH Dual Color Dual Fusion Probe ...
The clinicopathological spectrum of ALK-positive histiocytosis is broader than originally described, and this entity is characterized by frequent presence of KIF5B-ALK gene fusion. We recommend that every unusual histiocytic proliferative disorder, especially disseminated lesions, be tested for ALK expression...
HistiocyticALK-positive histiocytosisKIF5B-ALKfusionCentral nervous systemActa Neuropathologica -doi:10.1007/s00401-019-02027-7Calixto-Hope G. LucasAhmed GilaniDavid A. SolomonXiayuan LiangArie PerrySpringer NatureActa Neuropathologica
ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion.doi:10.1038/S41379-018-0168-6Kenneth Tou En ChangAmos Zhi En TayChik Hong KuickHuiyi ChenElizabeth AlgarNadine TaubenheimJanine Campbell
In addition, this KIF5B-RET gene fusion, 6/319 (2%) of Japanese lung cancer, has been detected in 1/80 (1%) of American lung adenocarcinoma. Then, the seven cases Both EGFR, KRAS, since did not show a known activating mutations such ALK oncogene, the gene fusions were found to be ...
These mutational changes are known to be mutually exclusive, but the co-existence of ALK rearrangement with activating mutations of EGFR is rarely found.We examined the KIF5B-RET fusion gene in frozen tissues from 154 surgically resected lung tumors using RT-PCR with direct sequencing and the ...
It was recently reported in nonsmall cell lung cancer (NSCLC) that the fusion protein encoded by echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) fusion gene conferred oncogenic properties. The objective of the current study was to identify other possible ALK fusion genes in NSCLC....
None of the seven subjects revealed known activating mutations such as EGFR, KRAS or ALK oncogenes; thus, said gene fusions were found to be responsible mutations (driver mutations) for oncogenesis. Since said gene fusions are considered to induce constitutive activation of RET tyrosine kinase ...