(2) the substance is filtered into the urine by theglomerulus, and (3) the toxin or its metabolites within the renal tubular lumens are concentrated. Nephrotoxins can do the following:
It may be caused by juxtaglomerular cell tumors, malignant kidney tumors (nephroblastoma, adenocarcinoma), or epithelial or soft tissue tumors. Primary reninism is associated with very high plasma renin concentrations and by the absence of RAS and intrarenal ischemia (as determined by renal ...
Emory University, Atlanta, GA; Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Background: Glomeruli are vascular structures that undergo architectural remodeling with disease (Dz) that is readily appreciable in a qualitative manner in routine nephropathology practice; however, ...
Nephroblastoma (Wilms tumor) is common in children and accounts for 5鈥 6% of all primary renal tumors. This chapter focuses on the classification, pathology, genetics, clinical and radiographic manifestations, and surgical and systemic management of the less common malignant and benign tumors of ...
Of these, renal cortical adenoma was the most common tumor (4 cases, 44%), followed by urothelial cell carcinoma (UCC) of the renal pelvis (2 cases, 22%), post-transplant lymphoproliferative disorder (2 cases, 22%) and oncocytoma (1 case, 12%). The mean age was 50 years (range 28...
Association of Tumor Necrosis With Pathological Features and Clinical Outcome in 754 Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothel... Seitz,C.,Gupta,... - 《Journal of Urology》 被引量: 83发表: 2010年 Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney:...
[21]. Although ferroptosis has gained prominence in recent years, iron’s potential nephrotoxic role was recognized as early as the 20th centur [22]. This review explores the molecular mechanisms of ferroptosis and its involvement in CKD development, providing novel insights for the prevention and...
The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectations. With self-renewal capabilities and grea
The modern era of renal surgery began on August 2, 1869 when the first plannednephrectomyon a living human being was performed. Eighteen years later in 1887, the firstpartial nephrectomyto remove arenal tumorwas performed. Both total and partial nephrectomy have become the hallmark surgical procedur...
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death contributes to the pathology of a plethora of renal diseases. Recently, with in-depth studies into kidney diseases