Kidney biopsy showed kappa light chain only proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID), crystalglobulinemia, light chain proximal tubulopathy with kappa light chain deposits, mild tubular atrophy and interstitial fibrosis. Free kappa light chain ratio was >1000 mg/dL...
Post-biopsy/nephrectomy treatment was mostly conservative (10), while some patients received immunosuppression (2, for minimal change/IN) or chemotherapy (1, for myeloma). Outcomes included improved (4) or stable serum creatinine (5), worsening serum creatinine (4), or end stage renal disease ...
Acute kidney injury is diagnosed initially by a change in serum creatinine levels, and then the etiology is determined by clinical history, lab testing, imaging, and possibly kidney biopsy . The management of AKI depends on the etiology; however, attention to the individual's volume status and ...
Design: Twenty-eight patients with MIDD in our 2004-2014 renal biopsy files at VUMC were reviewed. There were 22 patients with LCDD, 4 patients with LHCDD and 2 patients with HCDD. A semi-quantitative index G score (0-4) was used to evaluate the degree of glomerular mesangial expansion ...
Biopsy Percutaneous kidney biopsy is generally indicated when kidney impairment and/or proteinuria approaching the nephrotic range are present and the diagnosis is unclear after appropriate workup. See Workup for more detail. Management Early diagnosis and treatment of the underlying cause and/or institu...
A Case of Biopsy Proven Kidney Restricted AL Amyloidosis Leading to Diagnosis of Multiple Myelomadoi:10.1681/ASN.20213210S1824dRutu ShahAlexander PennekampJohn HergenrotherAmerican Society of NephrologyJournal of the American Society of Nephrology
Results: A total of 61 patients with multiple myeloma and biopsy-proven kidney involvement were included in the study. The mean age at presentation was 55.39 卤 11.91 years, with male predominance (male to female ratio -1.6:1). The most common lesion on kidney biopsy was my...
At presentation, 50% of patients with multiple myeloma have kidney dysfunction, which is considered a poor prognostic indicator. With the advent of newer therapies, physicians believe that a kidney biopsy does not make a significant difference in therapy. However, newer lesions like monoclonal ...
Post-biopsy/nephrectomy treatment was mostly conservative (10), while some patients received immunosuppression (2, for minimal change/IN) or chemotherapy (1, for myeloma). Outcomes included improved (4) or stable serum creatinine (5), worsening serum creatinine (4), or end stage renal disease ...
Design: Twenty-eight patients with MIDD in our 2004-2014 renal biopsy files at VUMC were reviewed. There were 22 patients with LCDD, 4 patients with LHCDD and 2 patients with HCDD. A semi-quantitative index G score (0-4) was used to evaluate the degree of glomerular mesangial expansion ...