Three pathologists with breast expertise each performed a blinded review with 3 different manual scoring methods [estimated (EST), unweighted (UNW), and weighted (WT) (WT recommended by the International Ki-67 in Breast Cancer Working Group)]. Quantitative image analysis (QIA) using the HALO ...
[13] Sinn HP, Schneeweiss A, Keller M, et al. Comparison of immunohistochemistry with PCR for assessment of ER,PR, and Ki-67 and prediction of pathological complete re-sponse in breast cancer[J]. BMC Cancer, 2017, 17: 124. [14] Cortazar P, Zhang L, Untch M, et al. Pathological co...
BRCA1/2基因突变,导致其抑制肿瘤发生的功能受到影响。研究表明,5%~10%的乳腺癌患者具有明确的遗传基因突变,称之为遗传性乳腺癌(hereditary breast cancer,HBC),其中BRCA1/2基因突变占15%。 携带BRCA1/2基因突变的女性不仅乳腺癌发病风险增加,其他如卵巢癌、输卵管癌、胰腺癌、胃肠癌及黑素瘤等发病风险也增加,男性...
1 In December 2020, the International Ki-67 in Breast Cancer Working Group (IKWG) set forth recommendations for establishing analytical validity for IHC evaluation for measuring Ki-67. But the panel of breast cancer experts said that evidence for Ki-67’s clinical utility is limited to its bei...
虽然目前仍无法确定原发病灶与脑转移病灶Ki-67指数的变化是否与患者的生存期有关,但这为今后的研究提供了方向。 参考文献 Chen JX; Zhou JM; Zhang HQ, et al. Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain. 10.21203/rs.3.rs-1692389/v1....
ERα and ERβ expression in correlation with Ki-67, Bcl-2 and Bak in primary tumors and lymph node metastases of breast cancer: The effect of pre-operative... aw.ERα and ERβ expression in correlation with Ki-67, Bcl-2 and Bak in primary tumors and lymph node metastases of breast ...
在同一种分型中,Ki-67越高不一定意味着预后越差。尽管通常对化疗敏感的是处于细胞生长周期中的细胞,而G0期的细胞对化疗不太敏感,但高Ki-67阳性率的肿瘤往往对化疗更敏感,因此化疗效果可能更好。 然而,Ki-67受到多种因素的影响,目前还没有统一的判断和评价指南,因此可能导致Ki-67评估存在差异。在预后评估中,除...
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of th
Ki-67%breast cancer subtype%chemotherapy%early-stage breast cancer%endocrine therapy%estrogen receptor-positive%gene expression assays%progesterone receptor Ki-67breast cancer subtypechemotherapyearly-stage breast cancerendocrine therapyestrogen receptor-positivegene expression assaysprogesterone receptor... Nobuyuki...
Triple negative breast cancer (TNBC) has a poorer survival, despite a higher response rate to neoadjuvant chemotherapy. The purpose of this study was to identify the predictive or prognostic value of Ki-67 among patients with TNBC treated with neoadjuvant chemotherapy, and the role of Ki-67 in...