Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current ...
O-GlcNAcylation: key regulator of glycolytic pathways 来自 Semantic Scholar 喜欢 0 阅读量: 41 作者:ZA Bacigalupa,CH Bhadiadra,MJ Reginato 摘要: Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, ...
This highly regulated form of glycolysis allows cells to efficiently budget their metabolic needs and may be a critical link between photoreceptor function and survival. Pyruvate kinase muscle isozyme 2 (PKM2) is a key regulator of ... TJ Wubben,M Pawar,A Smith,... - 《Scientific Reports》 ...
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells Cell proliferation only proceeds when metabolism is capable of providing a budget of metabolic intermediates that is adequate to ensure both energy regener... S Mazurek - 《Int J Biochem Cell Biol》 被引量:...
receptor α (ERα). Moreover, HBO1 participates in the expansion of medullary thymic epithelial cells (mTECs) and regulates the expression of peripheral tissue genes (PTGs) mediated by autoimmune regulator (AIRE), thus inducing immune tolerance. Furthermore, HBO1 influences the renewal of hematopo...
Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a ... HJ Knowles,NA Athanasou - 世界图书出版公司, 被引量: 206发表: 2008年 Clinicopathological significance of hypoxia-inducible factor-1 expression ...
The proportion of nascent mitochondrial read counts to total mitochondrial read counts was calculated in each single cell, and its distributions between cells with knockdown and NTC cells were compared by Kolmogorov–Smirnov tests to identify the master regulator of mitochondrial mRNA dynamics. In all ...
The upstream kinase LKB1 is a tumour suppressor, and AMPK may exert many of its antitumour effects. AMPK activation promotes the oxidative metabolism typical of quiescent cells, rather than the aerobic glycolysis observed in tumour cells and cells involved in inflammation, explaining in part why ...
Further,H19 depletion in HepG2 cells impaired insulin signaling and increased nuclear localization of FoxO1, an important transcriptional regulator of gluconeogenic gene expression. Our results reveal a novel link between decreased H19 levels and impaired gluconeogenesis via regulation of FoxO1 nuclear ...
Hypoxia has been shown to be a key regulator of MPO and iNOS in several gynecologic disorders 10, 12, 15. Previous studies have shown that shifting anaerobic to aerobic metabolism with the use of dichloroacetate (DCA) ameliorated the effects of hypoxia and the resultant oxidative stress by induc...