Partial reduction or complete ablation of tau prevented this behavioral abnormality in Scn1aRX/+ mice but did not affect repetitive self-grooming in Scn1a+/+ mice (Figure 1A), suggesting that the development of this autism-like behavior requires >50% of physiological tau levels, at least in ...
2015), reported variation of findings in terms of the extent of sexual abuse amongst children with intellectual disability, but confirmed that they are very vulnerable and at a higher risk of sexual victimisation in comparison to their counterparts with average intelligence. Those...
(H and I) Scatterplot of RE shifts during cell transitions: iPSC to NPC (H) and NPC to neuron (I). Zoomed-in view show most genes and overall density of points. Insets with the full range show outliers in RE values. Pie charts depict total number of genes with significant fold chang...
(iii) unlike empiricism, neuroconstructivism accepts some form of innately specified starting points, but unlike nativism, these are considered to be initially `domain-relevant', only becoming domain-specific with the process of development and specific environmental interactions; and (iv) different ...
time points labelled ‘L’ correspond to subsequent Larval developmental stages; WPP indicates the white prepupae and,‘P’ indicates pupal stage, ‘F’ and ‘M’ are for female and male adult stages respectively (see Additional file 1: Figure S1 for an example of a gene with a low TS sc...
Deng YY, Lu J, Ling EA, Kaur C (2011) Role of microglia in the process of inflammation in the hypoxic developing brain. Front Biosci (Schol Ed) 3:884–900 ArticleGoogle Scholar Derecki NC, Privman E, Kipnis J (2010) Rett syndrome and other autism spectrum disorders--brain diseases of...
The concerted change in interstitial ion concentrations during state transitions relies on the stable regulation of homeostatic set-points for these ions. The principle mechanism for maintaining ion homeostasis in the brain is the Na+, K+-ATPase. This electrogenic transporter extrudes 3 Na+ ions for...
it is expected that studies to improve the limitations and elucidate the mechanisms of the pathways involved will continue. Efforts are needed to clarify the mechanisms of drug delivery from the nasal cavity to the brain so that formulations can reach key points in nasal-to-brain drug delivery....
The growth and impact of video games in education at an international level is a reality. Research shows that gamers can increase their knowledge, skills, and behavioural flexibility. However, there has been no in-depth research into the relationship between current video games and the key compete...
sample (n = 16) was recruited in 2019 and 2020 (prior to the COVID-19 pandemic) using a snowball approach, to reflect domains and experiences of interest: opioid/substance use and the disabling conditions of mental health disorders, traumatic brain injury, spinal cord injury, Autism, and ...