Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction, Cell (2020), https://doi.org/10.1016/j.cell.2020.09.015 ll Resource Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction Daniel...
ResourceKey Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction Author links open overlay panelDaniel K. Wells 1 24 26, Marit M. van Buuren 2 3 24, Kristen K. Dang 4 24, Vanessa M. Hubbard-Lucey 5, Kathleen C.F. Sheehan 6 7, ...
A further example relates to an upregulation of tumor protein p53-inducible nuclear protein-1 (Tp53inp1). Tp53inp1 is a target of p53 but also of p73 [131], and its overexpression leads to apoptosis. The expression of Tp53inp1 is markedly increased in cells treated with doxorubicin or irradiati...
As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal. Previous studies have shown that tumor progression is closely related with tumor metabolism and m
Parameters of MaxQuant database searching were a false discovery rate (FDR) of 0.01 for proteins and peptides, a minimum peptide length of seven amino acids, a first search mass tolerance for peptides of 20 ppm and a main search tolerance of 4.5 ppm. A maximum of two missed cleavage...
of ADC carriers. Smaller formats such as mAb fragments (scFv, single-chain variable fragment, and Fabs, fragment antigen-binding) have been explored in this context (small-format drug conjugates) with the aim to enhance solid tumor penetration and cell internalization [12,13]. However, to date...
Elastic net hyper-parameters α and λ were both selected empirically per model by a grid search that maximized AUC under five-fold nested cross validation. 100 bootstrap resampling runs were used to estimate the 95% confidence interval for the AUC. Acknowledgments This work was supported by ...
Soilleux EJ, Roberts IS (2006) Assessment of the Cardiff nephrectomy cut-up protocol with total blocking of the renal sinus: effect on tumour staging and practical issues. J Clin Pathol 59:1209–1211 Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in re...
Although the host can mount an immune response against cancer cells [1] the fact that the tumor takes off in cancer patients demonstrates that tumor may elude immune defences [1, 2]. Tumors are not simple entities. They are composed of tumor cells, tumor stroma and often of a series of ...
(Vanquish UHPLC, Thermo, Waltham, MA, USA) using higher energy collisional dissociation fragmentation. The LC-MS/MS parameters are supplied in theSupplementary Materials. The 5 raw digestion data files were used to perform sequence coverage analysis with PEAKS Studio X (Bioinformatics Solutions Inc....