which develop mostly independently from larval light organs during the pupal stage. The mechanisms of adult light organ development have not been thoroughly studied until now. Here we show that key homeobox transcription factors AlABD-B and AlUNC-4 regulate the development of adult light organs...
Overrepresented motif analysis of open chromatin peaks identified caudal type homeobox 2 (CDX2) as a key activating transcription factor in HIO. but not in monolayer cultures of Caco2. However, the CDX2 motif becomes overrepresented in open chromatin from Caco2 cysts, reinforcing the importance of...
The finding that mutations in NKX2-2 and MNX1 can cause neonatal diabetes takes the number of genes in which mutations are known to cause PNDM from 18 to 20, of which 10 encode pancreatic transcription factors. Unlike previous studies, which have identified mutations in humans because of simil...
Expression of the transcription factor, aristaless-related homeobox (ARX), is also increased in the Gcg(gfp/gfp) pancreas. Here, we sought to elucidate the role of ARX in the hyperplasia of α-like cells through analyses of two Arx mutant alleles (Arx(P355L/Y) and Arx ([330insGCG]7/...
Foxo3a Foxo3a, a member of the forkhead homeobox type O filmily of transcription factors, is an important downstream effector of the PI3K/AKT pathway. Foxo3a normally resides in the nucleus, but it delocalizes to the cytosol upon growth factor stimulation which mediated by Akt activation. Akt ph...
OTX1is a homeodomain transcription factor and is encoded by Orthodenticle homeobox 1. In the mammalian brain,OTX1is expressed in the forebrain and midbrain during early stages of neural development27and at later stages and adulthood at high levels in layers 5 and 6, the deepest layers of the...
REVIEW The oncogene ERG: a key factor in prostate cancer P Adamo1 and MR Ladomery2 ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development...
Here, we show that the proximal upstream regions of six visual cycle genes contain chromatin-accessible sex-determining region Y box (SOX) binding sites, that SOX9 and LIM homeobox 2 (LHX2) are coexpressed in the nuclei of mature RPE cells, and that SOX9 acts synergistically with ortho...
Introduction:The transcription factor (TF) Iroquois homeobox 5 (Irx5) is a key patterning and differentiation regulator. In humans, IRX5 regulates the expr... R Canac,B Cimarosti,A Girardeau,... - 《Circulation》 被引量: 0发表: 2021年 IRX5 transcription factor can interact with GATA4, TB...
(2005). A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 123: 819–831. CAS PubMed Google Scholar Felli N, Fontana L, Pelosi E, Botta R, Bonci D, Facchiano F et al. (2005). MicroRNAs 221 and 222 inhibit ...