ONCOLYSIS MEDIATED BY INFB AND ARF GENE TRANSFER ACTIVATES KEY COMPONENTS OF THE IMMUNE SYSTEMBackground The importance of the immune system for controlling neoplasms was highlighted with the success of checkpo
Antonio Graca, Head of R&D at Sogrape inPortugal, explains: "The past climate – it's not going to happen again for the rest of our lives. Even if carbon emissions would stop today, the whole inertia of the global atmosphere would still keep on warming the planet for decades." ...
Specifically, we used a multivariate Poisson model to predict peak accessibility from single-nucleus RNA sequencing principal components. For 14 autoimmune diseases, we discovered that cell-state-dependent (‘dynamic’) chromatin accessibility peaks in immune cell types were enriched for heritability, ...
immunosenescence has steadily progressed over the past few decades and many studies on age-related immune decline have laid the foundation for identifying intervention methods [10, 21,22,23], the interactions between senescence-related changes and different components of the immune system remain unclear...
Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and immunosupp
We developed a new method, single guide RNA (sgRNA) lentiviral infection with Cas9 protein electroporation (SLICE), to identify regulators of stimulation responses in primary human T cells. Genome-wide loss-of-function screens identified essential T cell receptor signaling components and genes that ...
Why? It’s basic human nature combined with toxic corporate cultures that constantly shout at us to do more with less, to cut corners, to ship faster regardless of quality. You can have an instant podcast that doesn’t sound like garbage with no effort? Great! The same tools that give ...
The main components of the ECMO circuit are the oxygenator and the pump. Draining from the outflow cannula, blood enters the pump and is driven through the oxygenator. The oxygenated blood is returned to the patient via the inflow cannula [29]. The circuit has three primary modifiable settings...
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular RNA, etc., which play a crucial role i
However, the use of strategies activating different components of the innate immune system is still in its infancy but might find a place in clinical oncology. Among these real hub genes, AGXT was mainly enriched in the biosynthesis of antibiotics, carbon metabolism, glycine, serine and threonine...