This study was designed to examine whether the training-induced improvement in the plasma concentration of ketone bodies in experimental diabetes mellitus could be explained by changes in the activity of the hepatic ketone body synthesis pathway and/or the plasma free fatty acid levels. Diabetes melli...
hepatic ketone body synthesisketoacyl-CoA transferasemonounsaturated fatty acidnon-esterified fatty acidperipheral ketone body utilizationBackground: Monounsaturated fat (MUFA) also has glucose-lowering action, but its effect on ketone bodies is unknown. Objectives: To examine the effects of high-MUFA...
Ketone bodies(acetoacetate and b-OH-butyrate) are small, water-soluble circulatinglipidsproduced by the adult liver, that cross the blood-brain-barrier, as well as theplacental barrier. Acetone, the thirdketone body, is metabolically inert, but causes the fruity smell on the breath and in the...
differences exist in the capacity of these two cell lines to metabolize ketone bodies and also that substrate-level regulation of the ketone body-metabolizing pathway exists. These two lines therefore provide a potentially useful system in which the mechanisms of regulation of these enzymes may be ...
ketone body metabolism, suggesting that regulation of substrate utilization could be a mechanistic link between the cardiometabolic outcomes of obesity and the progression of cognitive decline. Here, we review ketone body metabolism in physiological and pathological conditions with an emphasis on the ...
These findings indicate that specific differences exist in the capacity of these two cell lines to metabolize ketone bodies and also that substrate-level regulation of the ketone body-metabolizing pathway exists. These two lines therefore provide a potentially useful system in which the mechanisms of ...
KetoneBodiesMetabolism ByDr.NivanZoheiry Overview Livermitochondriahavethecapacityto convertacetylCoAderivedfromfattyacid oxidationintoketonebodiestobeusedas alternativefuelbybodycells. Thecompoundscategorizedasketone bodiesare: 1-Acetoacetate 2-3-Hydroxybutyrate(β-hydroxybutyrate), 3-Acetone Overview ...
(i.e. similar to that of CHO), whereas the equivalent value for βHB is 0.89 [152]. However, estimation of oxidation rates of KBs is possible using indirect methods if values for the volume distribution of KBs (i.e. total amount of KBs in the body divided by plasma [KB]), and ...
Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells. Am. J. Physiol., 269:C22-C27.Hildebrandt, L. A.; Spennetta, T.; Elson, C.; Shrago, E. Utiliza- tion and preferred metabolic pathway of ketonebodies for lipid synthesis by ...
We propose here a major role of a different pathway initiated by the induction of oxidative stress in the mitochondria during increased ketolysis. Oxidative stress induced by ketone body metabolism is beneficial in the long term because it initiates an adaptive (hormetic) response characterized by ...