In this review, we discuss the roles of ketone body metabolism and its connectivity with cardiometabolic and neurodegenerative disorders. We highlight both canonical and noncanonical roles of ketone body metabolism in preventing these adverse health outcomes. Since ketogenic therapies have been useful in ...
The latter pathway leads to the biosynthesis of ribose mandatory for DNA synthesis and NADPH which is not formed during ketone body metabolism and is a key cofactor in lipid biosynthesis. Finally, ketone bodies by serving mainly biosynthetic purposes spare glucose for the emerge...
Because muscle also uses ketone bodies, and because the ketone body oxidation pathway differs from that of fatty acid oxidation, this study was initiated to determine whether there were differences in ketone body metabolism between obese and lean subjects. Plasma β-hydroxy-butyrate ( β-OHB) ...
系统标签: ketone bodies metabolism ketogenesis ketolysis coa KetoneBodiesMetabolism ByDr.NivanZoheiry Overview Livermitochondriahavethecapacityto convertacetylCoAderivedfromfattyacid oxidationintoketonebodiestobeusedas alternativefuelbybodycells. Thecompoundscategorizedasketone bodiesare: 1-Acetoacetate 2-3...
Ketone-body metabolism in glioma and neuroblastoma cells.: We have examined the metabolism of ketone bodies in neuroblastoma C1300 and glioma C6 cells, two esta
Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. It accounts for nearly 20% of all cancer-related deaths. However, the...
We have examined the metabolism of ketone bodies in neuroblastoma C1300 and glioma C6 cells, two established lines of neural origin. The three ketone body-metabolizing enzymes are present in cells of both lines in the relative proportions normally found in brain (D-3-hydroxybutyrate dehydrogenase<...
Medical aspects of ketone body metabolism. Ketone bodies are produced in the liver, mainly from the oxidation of fatty acids, and are exported to peripheral tissues for use as an energy source. They... GA Mitchell,S Kassovska-Bratinova,Y Boukaftane,... - 《Clinical & Investigative Medicine...
Unique metabolites involved in fatty acid biosynthesis and ketone body metabolism were upregulated, while metabolites of the kynurenine pathway were downregulated... M Langbl,J Rovelt,A Saruhanian,... - 《International Journal of Molecular Sciences》 被引量: 0发表: 2024年 Inhibitory Effect of Que...
Our data provide a newly identified alternative pathway of ketone body metabolism. The purpose of D-3HBcarnitine synthesis and its fate remain to be elucidated. proefschrift Soeters.indb 74 4-8-2008 9:13:21 D -3-hydrotyrylcarnitine: an altnative ktone body pthw ay 75 C hpter 5 ...