β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-α β-hydroxybutyrylation. Cell Rep. 41, 111724 (2022). Article CAS PubMed Google Scholar Nasser, S. et al. Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight...
despite representing only 2.0% to 2.3% of adult body weight. In conditions of low carbohydrate intake or fasting, the body uses ketones (acetoacetate and beta hydroxybutyrate [BHB]) as an alternative energy source to glucose. Ketones are normally ...
The ketogenic diet (KD) switches cell energy metabolism from carbohydrates to fatty acid and amino acid oxidation1, from which ketone bodies, such as β-hydroxybutyrate (BHB), acetone, and acetoacetate (AcAc), are generated2. A consensus is yet to be reached regarding whether physiologic effects...
Abstract Lysine β-hydroxybutyrylation (Kbhb) is a post-translational modification induced by the ketogenic diet (KD), a diet showing therapeutic effects on multiple human diseases. Little is known how cellular processes are regulated by Kbhb. Here we show that protein Kbhb is strongly affected ...
The ketogenic diet (keto diet) is a diet high in fat and low in carbs. Read on to learn about ketosis, and learn about the safety, health benefits, and risks of the ketogenic diet.
In the early 20th century, it was discovered that a diet primarily composed of fats could replicate the effects of starvation. These favorable outcomes of the ketogenic diet (KD) have been attributed to its influence on the production of ketones, including β-hydroxybutyrate, acetoacetate, and ...
The ketogenic diet (keto diet) is a diet high in fat and low in carbs. Read on to learn about ketosis, and learn about the safety, health benefits, and risks of the ketogenic diet.
beta-hydroxybutyrateketone bodiesDEPRESSIVE-LIKE BEHAVIORDOPAMINERGIC-NEURONSThe benefits of a ketogenic diet in childhood epilepsy steered up hope for neuroprotective effects of hyperketonemia in Parkinson's disease (PD). There are multiple theoretical reasons but very little actual experimental proof or ...
Based upon a combination of clinical experience and known mechanisms through which the ketone beta-hydroxybutyrate (BOHB) functions as both a fuel and regulatory signal, we have defined nutritional ketosis as an average serum BOHB concentration in the range between 0.5 mM and 4.0 mM as measured by...
When you’re on a keto diet and regularly in a state of ketosis, your body produces ketones, specifically BHB (ß-hydroxybutyrate), which is a strong anti-inflammatory chemical. BHB helps to inhibit the inflammatory pathways (NF-kB and COX-2) and also activates the AMPK (AMP-activated pr...