The 3-ketoacyl-ACP synthase III (FabH), a key enzyme for bacteria growth, catalyses the last step of the initiation of bacterial fatty acid synthesis. Rice bacterial blight is caused by the pathogenXanthomonas oryzaepv.oryzae(Xoo), which is widely studied as a model bacterium. Bioinformatics...
TheA. tumefaciensC58 Atu2127 gene encodes a predicted type III acyl-CoA transferase (annotated as CaiB) that seemed a likely candidate for conversion of glutarate to glutaryl-CoA via transfer of CoA from succinyl-CoA. The possibility that CaiB might provide glutaryl-CoA for the BioZ reaction w...
coelicolor by Replacement of the 3-Ketoacyl ACP Synthase III Initiation Enzyme, RedP The enzyme RedP is thought to initiate the biosynthesis of the undecylpyrolle component of the antibiotic undecylprodiginine produced by -deletion mutant o... SJ Mo,BS Kim,KA Reynolds - 《Chemistry & Biology...
Identification and Analysis of the Acyl Carrier Protein (ACP) Docking Site on β-Ketoacyl-ACP Synthase III The molecular details that govern the specific interactions between acyl carrier protein (ACP) and the enzymes of fatty acid biosynthesis are unknown. We i... YM Zhang,MS Rao,RJ Heath,...
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome min... Polyketide synthases (PKSs) are involved in the biosynthesis of many important natural products. In bacteria, type III PKSs typically catalyze ...
β-Ketoacyl-ACP synthase (KAS) enzymes catalyze Claisen condensation reactions in the fatty acid biosynthesis pathway. These reactions follow a ping-pong mechanism in which a donor substrate acylates the active site cysteine residue after which the acyl group is condensed with the malonyl-ACP accept...
et al. Identification and analysis of the acyl carrier protein (ACP) docking site on β-ketoacyl-ACP synthase III. J. Biol. Chem. 276, 8231–8238 (2001). Article CAS PubMed Google Scholar Tallorin, L. et al. Trapping of the enoyl-acyl carrier protein reductase-acyl carrier protein ...
ThefabB gene of E. coli encoding β-ketoacyl-ACP synthase I has been isolated by complementation and sequenced. The enzyme has been purified and its NH
尾-Ketoacyl-acyl carrier protein synthase III (FabH) is a particularly attractive target which catalyzes the initial step of fatty acid biosynthesis. In this review, fatty acid biosynthesis, recent advances in the research of FabH as well as related inhibitors are reviewed. Finally, we also ...
Summary:cDNA clones encoding a novel 3-ketoacyl-ACP synthase (KAS) have been isolated fromCuphea. The amino acid sequence of this enzyme is different from the previously characterized classes of KASs, designated KAS I and III, and similar to those designated as KAS II. To define the acyl ...