J. C. Lemos and C. Chavkin, “Kappa-opioid receptor function,“ in: Opiate Receptors , Pasternak G. W. (ed.) (2011), pp. 226 – 305.Kappa Opioid Receptor Function. Lemos, C. J,Chavkin, C. The Opiate Receptors . 2011Lemos JC, Chavkin C (2010) Kappa opioid receptor function. In...
阿片类止痛药通过结合位于中枢神经系统和周围神经系统的G蛋白偶联受体(G-protein coupled receptor, GPCR)家族中的阿片受体(Opioid receptor),激活下游七种G蛋白(Gi1、Gi2、Gi3、GoA、GoB、Gz、Ggustducin)信号通路,继而抑制神经元的兴奋性...
These contractions represent a function of the main enteric excitatory motor neuron of the colon31 and inhibition by opioid receptor agonists reflects at least partly, their abilities to reduce diarrhoea or cause constipation32,33. ICI204448 and asimadoline are both described as full or maximally-...
Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newly developed KOR-cre knockin allele, viral tracing, single-cell RT-PCR, and ex vivo recordings, we show ...
英文名称: Anti-kappa Opioid receptor 总访问: 289 国产/进口: 进口 半年访问: 20 产地/品牌: 进口/国产 产品类别: 抗体 规格: 0.1ml/100μg 0.2ml/200μg 最后更新: 2025-2-13 货号: FS0492 CAS 号: 参考报价: 2370 立即询价 电话咨询 ...
Lemos CJ, Chavkin C (2011) Kappa opioid receptor function. In: Pasternak CW (ed) The opiate receptors, 2nd edn. Humana Press, Totowa, pp 265–305 Chapter Google Scholar Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu Y-T, Spetea M, Liu-Chen L-Y, Schwarzer C, Mann ...
The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular pathways of KOR may be key to maintaining this benefit while minimizing side-effect liabilities. As for m
Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons J. Pharmacol. Exp. Ther., 359 (2016), pp. 319-328, 10.1124/jpet.116.235184 View PDFView articleView...
enous GABA Function The Neuroprotection of Kappa Opioid Receptor Agonist BRL52537 is Partly Through Enhancing Endogenous GABA FunctionThe Neuroprotection of Kappa Opioid Receptor Agonist BRL52537 is Partly Through Enhancing Endogenous GABA Functiondoi:10.1016/s1016-3190(08)60051-8...
Localization of kappa opioid receptor mRNA by in situ hybridization revealed high levels of signal in the neocortex, piriform cortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus. The expression of kappa opioid receptor mRNA in human brain, as estimated...