3. Roth, B.L. et al. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.Proc Natl Acad Sci U S A99, 11934-9 (2002). 4. Vardy, E. et al. Chemotype-selective modes of action ...
The nausea and/or vomiting can be associated with use of an opioid, such as morphine or fentanyl. The peripherally-restricted kappa opioid receptor agonist can be an L-amino acid-containing peptide, a D-amino acid-containing peptide, or a synthetic peptide amide, such as for instance, D-...
Formula: C19H25Cl2N3O3.C4H4O4 Solubility: Soluble to 25 mM in water with gentle warming and to 100 mM in DMSO Purity: ≥99% Storage: Store at +4°C CAS No: 126766-32-3 The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analys...
3.Xiao L, Wang Y.J., Zhang M.M., et al. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl- 6,14-endoethano-tetrahydronorthebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J...
Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy ACS Chem. Neurosci., 3 (2012), pp. 221-236 10.1021/cn200128x CrossrefView in ScopusGoogle Scholar 38. Whitby L. R., Ando Y., Setola V., Vogt P. K., Roth B....
非多托嗪 | kappa-1a 类鸦片活性肽拮抗剂,Fedotozine tartrate JO-1196CAS133267-27-3 123618-00-8 (free base)C22H31NO4.C4H6O6 MW 523.58Purity: 99%, >99%eeBiological Activity: kappa(1a) opioid receptor agonistReferences: M Delvaux. Pharmacolo
Wei Fu, Yujun Wang*, Wei Li*, Zhuibai Qiu, Jinggen Liu*, and Liming Shao*. SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.J Med Ch...
[Keywords]Opioidreceptor;Pefipher~lyrestrictedkappaopioidreceptoragonist:Analgesi a; Antiinflammati0n kappa阿片受体(kappaopioidreceptor,KOR)为阿 片受体的3个主要亚型(mU,kappa,delta)之一,属 于G蛋白偶联受体家族,在感觉神经元,背根神经 节细胞和初级传人神经元末梢中均有表达.早期的 ...
The chemistry of vicinal diamines 1998, Angewandte Chemie - International Edition A Potent New Class of κ-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-[(dialkylamino)methyl]piperazines 1993, Journal of Medicinal Chemistry View all citing articles on ScopusView full text ...
The present invention relates to novel short-chain peptides of the general formula (I), which are selective and peripherally acting KOR agonist, their tautomeric forms, their enanti