KAP1复合体在胚胎细胞中沉默逆转录病毒小鼠白血病病毒。 与这一假设一致,我们在这里表明KAP1缺失导致一系列ERV,特别是IAP元件在小鼠胚胎干细胞和早期胚胎中显著上调。 Figure 1 | IAP elements are upregulated in KAP1-depleted ES cells...
KAP1缺失导致一系列ERV,特别是IAP元件在小鼠胚胎干细胞和早期胚胎中显著上调。 Figure 2 | KAP1 controls IAP elements in embryogenesis. 我们进一步证明KAP1与DNA甲基化协同作用沉默IAP元件,并在IAP基因组的5'非翻译区(5’UTR)富含KAP1,KAP1缺失导致组蛋白3第九号赖氨酸残基三甲基化(H3K9me3)丢失,这是KAP1...
ERVsendogenous retrovirusesendogenous retrovirusesKDknockdownknockdownOEoverexpressionoverexpressionWe identified Zfp819, a KRAB zinc finger protein, as a novel pluripotency-related gene.Zfp819 functions in suppression of endogenous retroviruses in ESCs.Zfp819 interacts with KAP1, a universal co-repressor of ...
PJ Thompson,V Dulberg,KM Moon,... - 《Plos Genetics》 被引量: 44发表: 2015年 hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells. Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome stability. Transcriptional silencing of a subset...
mechanisms that act at various stages of the viral life cycle [2]. Nevertheless, many ERVs possess functional regulatory sequences that direct transcription at specific developmental stages and/or in specific tissues. A number of ERV subfamilies are particularly active early in embryogenesis [3],...
mechanisms that act at various stages of the viral life cycle [2]. Nevertheless, many ERVs possess functional regulatory sequences that direct transcription at specific developmental stages and/or in specific tissues. A number of ERV subfamilies are particularly active early in embryogenesis [3],...
reduceme枷V撕onof Eygene. C眦results firstlyproved thatKAP一1够sociated complexesmay bindt0 p一酉obin locus di】嘣my and negativelyregulate me genes inmeloc啦.Andwe如rtller涮 matl(AP.1缸eractswithMaⅨt0 negatiVelyregulatep-m旬0r百0biIl觚d ...
Eterkarboksylsyrer p basis av alkoksylerte merkaptobenztiazoler og deres anvendelse som korrosjonsinhibitorer Ether carboxylic acids derived from alkoxylated mercaptobenzothiazoles and their salts are new. Ether carboxylic acids of formula (IA), derived from alkox... M Feustel,U Dahlmann,R ...
We deleted the gene coding for the NCKAP1 subunit in BrafV600E;Pten loss‒driven melanomas in mice and found that loss of Nckap1 significantly reduced tumor burden and slowed tumor growth. NCKAP1 deletion led to altered signaling, increased tumor fibrosis, and enhanced infiltration by ...
KAP1缺失导致一系列ERV,特别是IAP元件在小鼠胚胎干细胞和早期胚胎中显著上调。 Figure 2 | KAP1 controls IAP elements in embryogenesis. 我们进一步证明KAP1与DNA甲基化协同作用沉默IAP元件,并在IAP基因组的5'非翻译区(5’UTR)富含KAP1,KAP1缺失导致组蛋白3第九号赖氨酸残基三甲基化(H3K9me3)丢失,这是KAP1...