In conclusion, our research elucidated the role of TNFAIP2 in promoting angiogenesis in breast cancer. TNFAIP2 promotes breast cancer angiogenesis via the Rac1-ERK-AP1-HIF1α axis. These findings indicate that TNFAIP2 could be a promising therapeutic target for TNBC. In the meantime, ERK inhi...
The ERK-AP1 pathway was activated under serum starvation in NPC cells, resulting in the expression of MMP9. In contrast, treatment with an MMP9 inhibitor or an MMP9 siRNA inhibited serum starvation-induced invasion. Conclusion: Serum starvation could up-regulate MMP9 expression in NPC cells, ...
to ERK2/AP1 activation. Additionally, the specific ERK inhibitor, PD980509, significantly suppressed ALV replication, as evidenced by extremely low levels of ALV promoter activity and ALV-J protein expression.In vivoanalysis of ERK2 activation in tumor cells derived from ALV-J-infected chicken demo...
Infection with other ALV subgroup (A/B) strains also triggered ERK/MAPK activation. Moreover, when activating ERK2, ALV subgroups A, B and J simultaneously induced the phosphorylation of c-Jun, an AP1 family member and p38 activation but had no obvious effect on JNK activation at either 15...
( 1993 ). Overexpression of mitogen-activated protein kinase (ERK1) enhances T-cell cytokine gene expression: role of AP1, NF-AT, and NF-KB . Blood , 82 , 2470 – 2477 .J.H. Park and L. Levitt, Overexpression of mitogen-activated protein kinase (ERK1) enhances T-cell ctyokine gene...
There are comments on PubPeer for publication: Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ (2006)
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Subsequently, in vitro experiments confirmed that SAA1 regulates ccRCC cell migration via the ERK-AP1-MMPs axis. In conclusion, our study has explored the potential value of the MMP family as prognostic markers for ccRCC and as guides for medication regimens. Additionally, we have identified SAA1...
Exogenous avian leukosis virus-induced activation of the ERK/AP1 pathway is required for virus replication and correlates with virus-induced tumorigenesis. Sci Rep. 2016; 6:19226.Dai, M., Feng, M., Ye, Y., Wu, X., Liu, D., Liao, M., et al. (2016a). Exogenous avian leukosis ...
In addition, BMPR2 directly interacts with upstream partne rs of RAF-ERK1/2 and its loss may alter their function. Disordered RAF-ERK1/2-AP1 signaling may contribute to the vascular remodeling characteristic of PAH.doi:10.1016/S0735-1097(14)61490-XAwad, Keytam Salem...