化学骨架:β-内酰胺类(beta-lactams) 作用机制(General mode of action):抑制细胞壁合成的某些阶段来发挥作用。细菌细胞壁(更多分布在革兰氏阳性菌)内主要的结构成分是一种称作肽聚糖的必须聚合物。β-内酰胺类结合青霉素结合蛋白(PBPs),此蛋白参与肽聚糖合成的最后阶段。通过抑制PBP功能,肽聚糖无法正常合成从而引起...
At the post-synaptic membrane the antibiotic desensitizes the receptors to acetylcholine, while the muscle relaxant acts by occupying the receptor.The mode of action of the antibiotic and muscle relaxant at the presynaptic membrane is similar to that of magnesium ions. The resistance to reversal of...
Moreover, aminoglycosides have exhibited inhibition of DNA synthesis [2,11] and RNA synthesis [2] as well as misreading in translation [3,4,16]. It was because of the pleiotropic effects of these antibiotics that scientists had trouble with an explanation of their mode of action that ...
The mode of action of DKB was considered to be mainly bactericidal. Antibacterial activity of DKB was weakened by addition of horse serum, or Ca, Mg, Fe or Al ion and was generally restored by the addition of EDTA with each agent. Therapeutic effects of DKB on GM against experimental s....
Genes and mutations are the reasons for kanamycin resistance. A bacterium may naturally be resistant to the drug. One such example is the nptII gene, which is found naturally in bacteria and which produces an enzyme that inhibits the action of kanamycin in the bacterial cell. This type of nat...
operating via new mechanisms of action distinct from those of the approved drugs. The use of CNT-based nano-delivery devices offers, so far, unmet approaches to explore nonclassical platinum(II) complexes withtrans-geometry or with a monofunctional coordination mode, polynuclear platinum(II) compounds...
FibrauretineAntibacterial activityMembrane integritySynergistic effectObjective The present study evaluated the antibacterial activity and mode of action of fibrauretine on Escherichia coli ( E. coli) and Staphylococcus aureus, and synergistic effect with kanamycin......
Regarding the possible mode of action of bekanamycin on transmitter release our results are consistent with the hypothesis that ther is competition between calcium and bekanamycin in the excitation-secretion coupling process and that the site of competition has a higher affinity for bekanamycin than ...
Engineering Escherichia coli to increase plasmid DNA production in high cell-density cultivations in batch mode. Microb. Cell Fact. 2012, 11, 132. [Google Scholar] [CrossRef] [Green Version] Trivedi, R.N.; Akhtar, P.; Meade, J.; Bartlow, P.; Ataai, M.M.; Khan, S.A.; Domach,...