信息来源:Switching to dolutegravir plus rilpivirine versus maintaining current antiretroviral therapy regimen in virologically suppressed people with HIV-1 and the Lys103Asn (K103N) mutation: 48-week results from a randomised, open-label pilot clinical trial Published:March, 2024DOI:doi.org/10.1016/S...
(2023). Efficacy of dolutegravir and rilpivirine for treatment-naive HIV-1-infected individuals with K103N resistance mutation: a multicentre, open-label, randomised phase 2b trial. The Lancet HIV, 10, e466-e474. O网页链接2、文中部分内容或图片来源网络,如有侵权,请联系删除。
The K103N mutation had no apparent impact on transmission fitness as its spread raised during the last years. These observations may impact on local prevention and ARV prophylaxis strategies.doi:10.7448/IAS.15.6.18201J RuelleM IngelsK Jnaoui...
The CD4 cell count has demonstrated some fluctuations during this period, but the CD4 percentage has remained relatively unchanged (Fig. 1b).In general, for those HIV-1-infected individuals who have a K103N mutation in their viral genotype, the intensification of a failing HAART regimen with ...
After treatment, the M184V mutation occurred less frequently among sdNVP-exposed women than among sdNVPunexposed women, but the frequency of NNRTI-associated mutations was similar between these groups of women with inadequate virologic response. Conclusions: Exposure to sdNVP in the prior 18-36 ...
Low-level drug resistance is not detected by routine consensus sequence genotype analysis (CSA) but low levels of specific mutations, such as the non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutation K103N, can be quantitated by allele-specific PCR (ASP). This study has ...
Detection of the HIV-1 K103N Resistance MutationAnubhav Tripathi
Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1-patient exposed to efavirenz for three weeks: a case report and review of the literature. J Med Case Rep. 2009; 3 :9132. http://dx.doi.org/10.4076/1752-1947-3-9132 ....
All except one of those sequences resulted from patients who were ARV-na茂ve at the time of sampling, and 21 had the K103N mutation. Two thirds of the clustered patients were infected through homosexual or bisexual contacts while the others were heterosexuals. No case was related to migrants...
Virus mutationThe structural rearrangement due to the unbinding of HBY 097 in K103N mutant HIV-1 reverse transcriptase ( RT ) was studied using two nanosecond molecular dynamics simulations. The simulations showed the dynamics of an open or upright position of the p66 thumb subdomain moving to ...