Effect of BRD4 inhibitor JQ1 on lung function in mice with chronic obstructive pulmonary disease and its mechanismLIU Xuejun, SHE Hui, ZHENG Lingrong, WANG Lingqiong.Department of Respiratory and Critical Care Medicine, Fuzhou Second Ho...
该研究使用了购AbMole 的 JQ1(M2167)和Zoledronic acid(M5032)两种产品。其中JQ1是BRD4的抑制剂,Zoledronic acid是一种可以抑制破骨细胞骨吸收,以及破骨细胞分化相关分子表达的化合物。 实验中使用JQ1抑制BRD4,并与BRD9被dBRD9降解后的转录谱相比较。发现两组差异最明显的是细胞周期和破骨细胞分化过程。并且细胞周期...
其中JQ1是BRD4的抑制剂,Zoledronic acid是一种可以抑制破骨细胞骨吸收,以及破骨细胞分化相关分子表达的化合物。 实验中使用JQ1抑制BRD4,并与BRD9被dBRD9降解后的转录谱相比较。发现两组差异最明显的是细胞周期和破骨细胞分化过程。并且细胞周期相关的特征基因在JQ1组明显下调(图9),提示其在破骨细胞生成过程中的潜在...
The present study aimed to explore the potential therapeutic effect of JQ1 on mechanical injury-induced mouse corneal scarring and TGF尾-induced human corneal myofibroblast differentiation and the related mechanism. The corneal scarring and myofibroblast differentiation were evaluated with clinical ...
for transcription elongation throughRNAPII, so can regulate transcription indirectly through control of the transcription preinitiation complex. Also, BRD4 has been proposed to act as an atypical kinase that can phosphorylate serine-2 of RNAPII, regulating transcription through a more direct mechanism.38,...
来自上海交通大学医学院的Jiahui Du,Yili Liu,Xiaolin Wu,Mingliang Zhou以及Xinquan Jiang等多名研究人员在Nature Communications期刊(IF=16.6)上,共同发表了题为“BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism”的文章,在该文章中,研究人员使用了购自AbMole的JQ1(...
Cancer epigenetics: from mechanism to therapy Cell (2012) M.J.Carrozzaet al. The diverse functions of histone acetyltransferase complexes Trends Genet. (2003) S.H.Baek When signaling kinases meet histones and histone modifiers in the nucleus ...
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly...
We found that Ad infection induced BRD4 and CDK9 association, an event that was exacerbated by JQ1 treatment, suggesting that JQ1 likely regulates transgene expression by gene transcription. The conclusion was demonstrated using Ad2 and Ad5-based vectors, it is likely that the mechanism may apply...
NF-κB/p65 (Lys310) acetylation and NF-κB p65/DNA binding activity in the lung tissues.#The BRD4 inhibitor JQ1 can downregulate MMP-2 and MMP-9 expression, reduce inflammatory responses, and alleviate oxidative stress in mice with COPD, and this mechanism might be related to the inhibition...