(+)-JQ-1 是 BET 家族共激活蛋白 BRD4 的一种有效的噻吩二氮卓抑制剂 (Kd=90 nM),通过 MYC 致癌基因的转录控制参与癌症的发病机制。(+)-JQ-1 的剂量范围研究证明有效抑制 H4Kac4 结合,小鼠 BRDT (1) 的 IC50 值为 10 nM,人 BRDT (1) 的 IC50 值为 11 nM[3]。 体内研究 已确定肿瘤的匹配小...
溶媒表观遗传修饰在神经炎症中起着重要作用,溴域结构域蛋白4(BRD4)作为一个关键的表观遗传学"阅读器"在急性炎性痛中的作用及机制尚不清楚.本实验将70只雄性ICR小鼠随机分为生理盐水组(NS,n=10),福尔马林组(PF,n=10),溶媒组(Vehicle,n=10),溶媒+福尔马林组(Vehicle+PF,n=10),12.5mg/kgJQ-1+福尔马林...
(B) Co-IP analysis of BRD4/RelA-K310ac with RelA-K310ac/BRD4 in rats kidney tissues treated with CdCl2 and JQ1. IgG was used as a negative control. 4. Discussion Cd has been reported as a potential trigger of inflammation because of its high toxicity, while the exact mechanism is ...
Signal-induced proliferation-associated protein 1 (SIPA1) is known to be a GTPase activating protein. Overexpressed SIPA1 is related to metastatic progress... T Takahara,A Kasamatsu,M Yamatoji,... - 《Experimental Cell Research》 被引量: 4发表: 2017年 Bromodomain‐containing protein 4 inhibitio...
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作为一名教师,她总是善于发现年轻人身上的长处和闪光点。鲁景超觉得,80后、90后甚至是00后的身上有很多优点是老一代人所不具有的。
Consistently, the level of FSP1 was greatly reduced in HEK293T and HeLa cells with stable BRD4 knockdown compared to control cells. Furthermore, ChIP-sequencing data showed that BRD4 bound to the promoter of FSP1, but the BRD4 binding was greatly reduced upon JQ-1 trea...
Conclusion In conclusion, lncRNA LBX2-AS1 promotes the growth of OS and represses the sensitivity to JQ-1 by sponging miR-597-3p to elevate the expression of BRD4.doi:10.3389/fonc.2023.1139588Jiayu LiXuhui YuanCong MaJunhong LiGaoyang Qu...
Similar results were obtained from pharmacological inhibition with JQ1 in human CRC organoids; IL33 expression was decreased, and IFNγ-induced apoptosis was attenuated in the presence of JQ1. Conclusions: Our results showed that the inhibition of Brd4 suppressed IFNγ-induced cytotoxicity by ...
We uncovered that abnormal increases in chromatin binding of BRD4 and enhancer-promoter interactions underlie the abnormal transcription in MeCP2 mutant INs, which were recovered to normal levels by JQ1. We revealed cell-type-specific transcriptome impairment in MeCP2 mutant region-specific human ...