Citation: Journal of Translational Medicine 2024 22:307 Content type: Research Published on: 25 March 2024 View Full Text View PDF Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a health...
7A). We demonstrated that antagomir-217-5p could effectively elevate SIRT1 expression and suppress the acetylation of β-catenin in the lung tissue of PQ-poisoned mice (Fig. 7B, C). Then, the evaluation of pulmonary fibrosis was conducted using H&E and Masson's trichrome staining techniques...
Abstract figure legend An endogenous AhR ligand (ITE) elevates maternal blood pressure and proteinuria in pregnant rats, and decreases uteroplacental blood flow and fetal and placental growth, all of which are hallmarks of preeclampsia. ITE also reduces vascular density, alters immune cell distribution...
The tetracycline transactivator (tTA) system provides controllable transgene expression through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment for transgene control in mouse models of disease might have undesirable
Third, off-target effects limit the clinical application of HDACis. It has been reported that in breast cancer models, HDAC inhibition elevates histone acetylation at the LIFR gene promoter and triggers the JAK1-STAT3 signaling pathway [127]. This suggested that HDACis might also lead to the...
S7E). However, only mutations at K57 (K57R) or K405 (K405R) displayed a modest increase in LTF expression compared to the wild-type LTF, with SENP3 overexpression failing to elevate the levels of these mutants (Fig. 5M). As anticipated, the mutants K57R and K405R exhibited a ...
Lactate and lactylation levels elevate after SCI After SCI, the hypoxic microenvironment regulates lactate levels at the injury site [12]. We detected changes in lactate levels in the injured spinal cord. The colorimetric assay revealed a significant increase in lactate levels at the lesion site ...
The Antioxidant activity of RJ can be attributed to the free radical scavengers; they can inhibit lipid peroxidation [62] via scavenging hydroxyl radicals [63], and they attributed this activity to three dipeptides containing tyrosine residues. Additionally, RJ inhibits the enzymes that elevate the ...
The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide ...
Our research posits a novel post-transcriptional regulation mechanism, wherein circMARK2, in conjunction with IGF2BP2, elevates LIN28B expression through forming circMARK2/IGF2BP2/LIN28B mRNA ternary complex, thereby elucidating an additional layer of complexity in the oncogenic landscape of WT....