Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study Carlota Castro-Espin ,Manon Cairat &Laure Dossus Article 24 September 2024|Ope
Also, attrition rate or high rate of failed clinical studies may be in part due to a lack of biomarkers (among others). Therefore, identifying biomarkers is essential in drug development, not only to provide proof of mechanism but also to refine targets and evaluate proof of concept. This ...
Medicine in Drug Discoveryis a peer-reviewed open access journal. The journal publishes original papers related to basic, preclinical and clinical studies covering all aspects of drug discovery and development. Clinical studies with a focus on efficacy and safety, target engagem...
The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early dia...
Some of them are also used in the pharma industry to know drug optimization in drug development. This journal seeks high quality of journals related to new research of biomarkers and their usage in different fields. Open access journal is an innovative platform, in which all articles are ...
Predicting reperfusion injury and functional status after stroke using blood biomarkers: the STROKELABED study Ischemic stroke is a leading cause of disability and mortality, particularly among the elderly. Recanalization therapies, including thrombolysis and thrombectomy, are essential for restoring blood ...
This review reports on recent advances in LC-MS/MS approaches for OS lipidic biomarkers, focusing on overcoming analytical challenges. 3 different classes of biomarkers have been reported, malondialdehyde, isoprostanes and oxidised sterols. For each class, the main analytical challenges with a ...
the molecular characterization of cancers and the importance of biomarkers for the development of novel antitumor therapeutics. We also review critical successes and failures in oncology, and detail the lessons learnt, which may aid in the acceleration of anticancer drug development and biomarker ...
Medicine in Drug Discoveryis a peer-reviewed open access journal. The journal publishes original papers related to basic, preclinical and clinical studies covering all aspects of drug discovery and development. Clinical studies with a focus on efficacy and safety, target engagement, biomarkers, … ...
Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models Petros A. Tyrakis Domen Kampjut Oliver D. K. Maddocks ArticleOpen Access13 May 2025 Biomarkers of response to camrelizumab combined with apatinib: ...