NF-kappa BapoptosisJNKinflammationcancerreactive oxygen speciesGadd45 betaTNF alphaNF-B/Rel transcription factors block apoptosis or programmed cell death (PCD)induced by tumor necrosis factor (TNF)卤. The antiapoptotic activity of NF-B is alsocrucial for immunity, lymphocyte development, tumorigenesis,...
NF-κB是一种重要的多效性核转录因子,可与多种基因启动子部位的κB位点发生特异性结合而促进其转录表达[23]。在正常状态下NF-κB与IκB以复合物的形式存在于细胞质中,当受到外来刺激如病原体LPS入侵后,IκB发生磷酸化作用,进而IκB发生泛素化被蛋白酶体降解,从而释放NF-κB使其由细胞质进入到细胞核内,与细胞...
决定因素之一.核因子一B(NF—B),c—Jun 氨基 末端激酶(JNK)通路在细胞凋亡中的作用已逐渐 被认识,现对NF—B,JNK 通路与高糖下内皮细 胞凋亡的关系作一综述. 1NF-KB,JNK 结构与生物学 NF—B 属于Rel/NF—B 家族成员,在哺乳 基金项目:卫生部科学研究基金(编号WKJ2005—2—021) ...
6.张代娟,刘江月,王建英.3,4-二羟基苯乙酮抑制NF-κB核转位减轻脂多糖诱导巨噬细胞炎症反应[J].实用医学杂志,2018,34(7):1092-1095. Zhang DJ,Liu JY,Wang JY.3,4⁃DHAP inhibits NF⁃kappa B nuclear translocation ...
MAPKs were involved in the activation of NF-κB p65 in Fe2+-stimulated SH-SY5Y cells. (A) Both carvacrol and JNK inhibitor, SP600125, inhibited NF-κB p65 translocation in Fe2+-stimulated SH-SY5Y cells, while ERK and p38 inhibitors did not. (B) Fe2+ induced IKK phosphorylation in SH-...
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 规格价格库存数量 1 mg ¥ 866 现货 5 mg ¥ 2,650 现货 10 mg ¥ 3,860 现货 25 mg ¥ ...
in the category "positive regulation of I-kappaB kinase/NF-kappaB cascade", the gene for inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE), which stimulates the dissociation of NF-κB and its inhibitor [46], was found to be up-regulated by TNFα treatmen...
The activation of NF-κB inhibits apoptosis via a mechanism involving upregulation of various antiapoptotic genes, such as cellular FLICE-inhibitory protein (c-FLIP), Bcl-xL, A1/Bfl-1, and X chromosome-liked inhibitor of apoptosis (XIAP). In contrast, th
in the category "positive regulation of I-kappaB kinase/NF-kappaB cascade", the gene for inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE), which stimulates the dissociation of NF-κB and its inhibitor [46], was found to be up-regulated by TNFα treatmen...
Tumor necrosis factor-α induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: The role of NF-kappa B, JNK and p38 MAPK. Neuropharmacology, 2007, 52: 708–715 71 Curran B P, Murray H J, O'connor J. A role for c-Jun N-...