Signs and symptoms: - Multifocal neurological deficit. - Symptoms depend on the location of lesions. - Hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment, clumsiness, and personality changes. • Diagnosis: - MRI - CSF PCR → viral DNA • Treatment: - Highly active antiretroviral...
JC virus JC polyomavirusis one of the viral infections that can causeneurologic symptomsin transplant recipients. The virus is ubiquitous in the normal population and causes disease only in the setting of impairedcellular immunity. Virulence depends on rearrangements in the regulator region of the viru...
They demonstrate positive JCV DNA findings in only 3 of 1.305 (0.2%) natalizumab-treated multiple sclerosis (MS) patients. None of these patients developed clinical progressive multifocal leukoencephalopathy (PML). In addition, they report 5 patients who developed symptoms of PML with negative JCV ...
virus (HIV), or having acquired immune deficiency syndrome (AIDS), hematologic malignancies, or an autoimmune disease such as systemic lupus erythematosus (SLE), an inflammatory bowel disease, such as Crohn's Disease (CD) or ulcerative colitis, multiple sclerosis (MS) or arthritis, e.g., ...
DNAJC12 has been described to regulate the stability of PAH and mutations in its gene cause hyperphenylalaninemia and neurological symptoms in patients. We show that DNAJC12 also binds and stabilizes TPH1 and TPH2 in transfected cells. In order to clarify the importance of DNAJC12 in the ...
.Cross-sectional study of quality of life and symptoms in chronic renal disease patients:The modification of diet in renal disease study[J].1997,29(06)... Michael V. Rocco MD, MS a b c,Jennifer J. Gassman PhD a b c,Shin-Ru Wang MS a b c,... - 《American Journal of Kidney Dis...
Transplant recipients who require immunosuppression, have HIV/AIDS, have malig- nancies, and/or receive routine infusions of biologics to treat autoimmune and inflamma- tory diseases, such as MS or Crohn's disease, should be monitored for abnormal neurologi- cal signs and symptoms associated with...
JCPyV is thought to persist in the kidneys, and asymptomatic individuals secrete virus in the urine [13,14]. However, human polyomaviruses can all cause seri- ous and often untreatable disease under immunosuppressive conditions, including those caused by lymphoproliferative disorders, HIV/AIDS, and ...
The Quality of Life in Neurological Disorders (Neuro-QOL) fatigue subscore was analyzed linearly and categorically using T-score cutpoints, with a period of elevated symptoms defined as T-score >= mean + 0.5 SD over follow-up. Results: At baseline, of 4012 participants (average age: 45.6 ...
Pharmacologic Rescue of Motivational Deficit in an Animal Model of the Negative Symptoms of Schizophrenia Deficits in incentive motivation, the energizing of behavior in pursuit of a goal, occur in many psychiatric disorders including schizophrenia. We previous... EH Simpson,C Kellendonk,RD Ward,.....