Polyomavirus JC (JCV) has been implicated in the etiology of multiple sclerosis (MS), because it causes progressive multifocal leukoencephalopathy (PML), a multifocal demyelinating disease with many microscopal similarities to MS. During childhood, the virus establishes a latent infection in the ...
JC polyomavirusis one of the viral infections that can causeneurologic symptomsin transplant recipients. The virus is ubiquitous in the normal population and causes disease only in the setting of impairedcellular immunity. Virulence depends on rearrangements in the regulator region of the virus. The ...
Anti-JC virus (JCV) antibody testing has been used increasingly to stratify multiple sclerosis (MS) patients into different disease modifying therapies.#We assessed JCV serostatus stability longitudinally in MS patients who were regularly tested for anti-JCV antibody and examined the demographic and ...
Background The risk of progressive multifocal leukoencephalopathy (PML) caused by the JC virus (JCV) is increased in patients with multiple sclerosis receiving biological therapies. Objectives To determine the seroprevalence of anti-JCV antibodies in Finnish patients with multiple sclerosis (MS) and clin...
摘要: Anti-JC virus (JCV) antibody index is the predictive factor of progressive multifocal leukoencephalopathy (PML) for multiple sclerosis (MS) patients treating with natalizumab. The aim of this study...关键词: Multiple sclerosis JC virus Natalizumab Anti-JCV antibody positivity and index ...
OBJECTIVE: To investigate the rate of seropositivity of anti-JC virus (JCV) antibodies in a German multiple sclerosis (MS) cohort treated with natalizumab in the postmarketing setting and to assess anti-JCV serostatus in samples obtained before diagnosis of progressive multifocal leukoencephalopathy (...
Anti-JC Virus Serostatus Changes Before and During the COVID-19 Pandemic in US Patients with Multiple Sclerosis (MS) Treated with Natalizumab (P12-3.007) S Krieger,S Sinks,F Huang,... - 《Wednesday April》 被引量: 0发表: 2023年 Association of PTSD With Longitudinal COVID-19 Burden in ...
The human polyomavirus JC virus (JCV) is responsible for the CNS demyelination observed in cases of progressive multifocal leukoencephalopathy. The JCV regulatory region (promoter) is a hypervariable, noncoding, nucleotide sequence positioned between the early and late protein-coding regions in the vi...
A genotype of JC virus (JCV) DNA extracted from human urine can serve not only as a means of elucidating human migration patterns, but also of tracing the origin of unidentified cadavers. If a JCV genotype is determined using a small amount of urine or urine stain from a given person, it...
JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients p pBackground/p pThe use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albei... R Mancuso,M Saresella,A Hernis,.....