从KEGG图中可以看到,STAT作为转录组因子激活的下游基因涉及细胞凋亡、细胞周期等通路的关键基因,包括Bcl-2、Bcl-XL、CycD、c-Myc等以前的章节提过的基因。STAT家族蛋白在恶性肿瘤发生发展中发挥多种作用,不同家族成员甚至有相反的作用。STAT3能抑制抗肿瘤免疫反应外,...
在前文提到的kegg核心35通路中(下图),JAK-STAT通路一共与8个通路存在直接连接。里面包括我们上文提到过的PI3K-Akt通路、MAPK通路,还包括Pathway in cancer。是的,JAK-STAT就是1个在肿瘤中起着重要作用的通路,而且可以通过独特的方式将各个相关通路串联在一起。 图1 JAK-STAT通路在35个核心通路中与其直接相关的...
02信号通路的筛选方法在伴学营课程中,老师也会讲到信号通路的筛选方法,包括常用的信号通路筛选方法和生物芯片筛选方法.03检索信号通路的数据库在检索信号通路时,常用的数据库就是KEGG数据库。在伴学营中,老师会详细介绍KEGG数据库的常用功能...
那就跟随小编来看看这篇文章,是由上海交通大学崔玖洁、王理伟、苏州大学及同济大学团队共同合作在Molecular Cancer上发表的题为Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib的研究论文 题目:ARNTL2激活PI3K/AKT信号通路可促进细...
All the identified 116 genes were annotated through Gene Ontology and mapped to the KEGG chicken JAK-STAT signaling pathway. To the best of our knowledge, this is the first study to represent the transcriptional analysis of a large number of candidate genes, regulators, and potential interactors ...
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we demonstrate that JAK-STAT signaling, beyond it
Hierarchical clustering was performed based on the JAK/STAT signaling cascade or the entire JAK/STAT gene set from KEGG and used to determine subgroup affiliation of 763 subtyped primary MB samples previously profiled on the Affymetrix Gene 1.1ST arrays5 and normalized using the RMA method (GSE85...
Introduction to Hedgehog Signaling Hedgehog Protein Synthesis and Relea 06:38 Introduction to RANKL RANK OPG Signaling Pathway 08:04 IP3 DAG Pathway( Gq signalling) 06:03 JAK STAT Signaling Pathway Regulation 04:52 JAK-STAT Signaling Pathway 09:19 JAK-STAT Signalling Pathway 03:38 JAK-STAT Pathw...
心源性脑卒中患者超急性期外周血miRNA与mRNA整合研究 miR-106b-5 p,miR-30d-5 p,miR-223-3p,miR-26 a-5 p与CE-mRNA存在广泛的相互作用关系,GO和KEGG分析表明CE-mRNA在IL-6介导的信号通路,JAK-STAT介导的... 周搏,郭晓玲,冯品,... - 《中国保健营养》 被引量: 0发表: 2019年 加载更多0关于...
(mouse) for these kinases were then used to map to KEGG IDs for pathway enrichment analyses, which defined 23 signaling pathways (Supplementary Table2). Because the same phosphopeptides can be mediated by different kinases, it is rare to have definitive cognate phosphopeptides for individual kinases...