百度试题 题目31.JAK-STAT信号通路(JAK- STAT signaling pathway) 相关知识点: 试题来源: 解析反馈 收藏
百度试题 题目29.JAK-STAT信号通路(JAK- STAT signaling pathway) 相关知识点: 试题来源: 解析反馈 收藏
百度试题 题目116.JAK-STAT信号通路(JAK- STAT signaling pathway) 相关知识点: 试题来源: 解析反馈 收藏
从靶点来说,与JAK1-3家族成员参与更广泛的全身信号通路不同,TYK2几乎只影响免疫相关信号传导,比如仅能介导IL-23、IL-12和I型干扰素等细胞因子,促进IL-17、IL-23等炎症性细胞因子的生成(自免关键通路),对其他细胞因子干扰较小,因此成药安全性高。 除了靶点本身的...
Our scientists have been hard at work trying to better understand the JAK-STAT cell signaling pathway over the years. For further information on this pathway please see our publications, white papers and posters: Publication: Cellular LanthaScreen and Beta-lactamase Reporter Assays for High-th...
Morgan Bldg., Lexington, KY 40506 , USA The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of ...
Janus tyrosine kinases JAK, signal transducer activator transcription STAT, signaling pathway metabolism, proliferation, apoptosis, leukemias, lymphomas, cancers.
‹细胞信号通路 JAK-STAT JAK-STAT Pathway Overview Akt › 炎症反应通路 › Integrin › 干扰素(IFN) › MAPK 细胞信号通路 › T细胞受体(TCR) › Toll样受体(TLR) › 肿瘤坏死因子(TNF) › To find antibodies, assays, and proteins associated with the JAK-STAT pathway, click on the ...
作为JAK-STAT信号通路的核心,JAK家族激酶参与了细胞增殖、分化、凋亡以及免疫调节等多种重要的生物学过程。因此,只要抑制JAK激酶,就可以阻碍相关肿瘤、血液系统疾病、类风湿性关节炎等疾病的发生。 进入21世纪以来,JAK激酶家族成为药物研发的热点,也取得了不少成果。2011年11月,全球第一款JAK抑制剂Ruxolitinib(芦可替尼...