JAK-STAT信号通路的基本作用机制如下: 配体与受体结合:细胞因子、激素或生长因子等配体与细胞膜上的受体结合,导致受体二聚化或构象变化。 JAKs激活:受体二聚化或构象变化使得与之结合的JAKs相互靠近并发生交互的酪氨酸磷酸化,从而激活JAKs。 STATs磷酸化:活化的JAKs磷酸化受体及其下游的STATs分子,使STATs的酪氨酸残基发...
Janus激酶(JAK)信号转导和转录激活因子(JAK-STAT)途径是一种进化上保守的信号通路,由细胞因子刺激激活,使细胞外信号通过细胞膜传递到细胞核,引起DNA转录的改变,在几个关键的生理过程中发挥作用,包括造血、分化、代谢和免疫调节。在结构上,JAK-STAT途径涉及跨膜受体、受体相关的胞质酪氨酸激酶(即JAK)以及信号转导和...
JAK-STAT 信号通路(JAK-STAT signaling pathway)由三个部分组成:细胞表面接收信号的酪氨酸激酶相关受体、传递信号的酪氨酸激酶 JAK(Janus kinase)和产生效应的信号转导和转录激活因子 STAT(Signal Transducer and Activator of Transcription)。...
et al. Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Sig Transduct Target Ther 8, 204 (2023). doi.org/10.1038/s41392- RL, Wang Y, Cheon H, et al. The JAK-STAT pathway at 30: Much learned, much more to do. Cell. 2022;185(21):3857-3876. ...
JAK-STAT signaling pathway also plays a crucial role in the central nervous system, where it regulates the processes of nerve cell proliferation and differentiation, apoptosis, and neuroinflammation. In addition, this pathway also is involved in neuroprotection and synaptic plasticity, which contributes ...
JAK/STAT的负调节主要涉及以下三个负调节因子:细胞因子信号转导抑制蛋白 (suppressors of cytokine signaling、SOCS)、活化STATs蛋白抑制因子(protein inhibitors of activated stats、PIAS)、蛋白酪氨酸磷酸酶(protein tyrosine phosphatases、PTPs)。另外还有很多负性调节...
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