在"2+结合至这些GLA残基后,丝氨酸蛋白酶活性变得很显著。许多血液凝固级联的丝氨酸蛋白酶(因子II、VII、IX和X)都含有该维生素K依赖的GLA残基。因子IXa切割因子X并致使活化为因子Xa。形成因子IXa的必要条件是由Ca"和因子VIIIa、IXa及X在激活的血小板表面上形成tenase复合体。活化的血小板的反应之一是磷脂酰丝氨酸和...
百度试题 结果1 题目17.华法林的抗凝血机制是 ( ) A.能对抗凝血因子IIa、VIIIa、IXa、Xa的作用 B.影响凝血因子II、VII、IX、X的合成 C.加速ATIII对凝血因子的灭活作用 D.激活纤溶酶 相关知识点: 试题来源: 解析 17. B 反馈 收藏
凝血因子缺乏症血友病A获得性因子 VIII缺乏症+ [1] 非在研适应症- 原研机构 Chugai Pharmaceutical Co., Ltd. 在研机构 Hoffmann-La Roche, Inc.罗氏(中国)投资有限公司Roche Registration Ltd. + [7] 非在研机构- 最高研发阶段批准上市 首次获批日期 ...
凝血过程中激活X因子生成Xa的物质是()。A.PF3B.VIIIa因子C.IXa、VIIIa因子、PF3及Ca2+组成的复合物D.Ca2+
Factor VIIIa is a non-covalent heterotrimer of A1, A2, and A3-C1-C2 subunits. Previously, we speculated that the central portion of the A2 subunit, in and around the activated protein C-sensitive bond at Arg562-Gly (Fay, P. J., Smudzin, T.M., and Walker, F.J. (1991) J. ...
作者: T Kitazawa,T Igawa,Z Sampei,A Muto,T Kojima,T Soeda,K Yoshihashi,Y Okuyama-Nishida,H Saito,H Tsunoda 展开 摘要: Hemophilia A is a bleeding disorder resulting from coagulation factor VIII (FVIII) deficiency. Exogenously provided FVIII effectively reduces bleeding complications in patients ...
百度试题 题目肝素增强抗凝血酶III灭活下列哪组凝血因子A.IIa、VIIa、IXa、Xa、XIIaB.IIa、IIIa、IVa、Va、VIIaC.IIa、VIa、VIIa、VIIIa、IXaD.IIa、VIIa、VIIIa、IXa、XaE.IIa、VIIa、VIIIa、Xa、XIIa 相关知识点: 试题来源: 解析 A 反馈 收藏
Inhibitory antibodies directed against factor VIII develop in a substantial number of patients with hemophilia A as a consequence of factor VIII replacement therapy. These antibodies usually recognize discrete epitopes within the A2 and/or the C2 domains of factor VIII. Here, we have characterized the...
百度试题 题目利伐沙班的作用机制是直接抑制()因子 A.XaB.VIIIC.IIID.IXa相关知识点: 试题来源: 解析 A 反馈 收藏
Individuals with hemophilia A lack the coagulation factor FVIII and are treated with frequent intravenous injections of FVIII agents. However, many individuals develop antibodies to FVIII and can no longer be treated by FVIII injection. Takehisa Kitazawa