VLDL or LDL cholesterol: which is more atherogenic?doi:10.1016/S0021-9150(00)80712-1StephenG. YoungElsevier Ireland LtdAtherosclerosis
Very‐low‐density lipoprotein (VLDL) and LDL with apoC‐III have varying amounts of apoE. We hypothesized that a high content of apoE lessens the adverse influence of apoC‐III on the risk of CHD because it promotes the clearance of VLDL and LDL from plasma. Methods and Results: We ...
42Usui S, Kakuuchi H, Okamoto M, Mizukami Y, Okazaki M. Differential reactivity of two homogeneous LDL-cholesterol methods to LDL, and VLDL subfractions, as demonstrated by ultracentrifugation and HPLC. Clin Chem 2002; 48:1946–54.10.1093/clinchem/48.11.1946Search in Google Scholar ...
Insulin inhibits hepatic very low density lipoprotein (VLDL) apo B secretion in rats. Current studies test whether the insulin effect is LDL receptor-mediated by examining the effect of insulin on VLDL apo B secretion in hepatocytes derived from Ldlr-/- and control mice. Primary hepatocytes were...
Increased VLDLs and the accompanying hypertriglyceridemia underlie the synthesis of small, dense LDLs with lower affinity for the LDL receptor. Oxidized LDLs could bind scavenger receptors and promote an inflammatory response. An overexpression of inflammatory cytokines could activate cholesterol synthesis ...
ApoB, remember, is the concentration of LDL and vLDL particles. And what do they carry? Cholesterol and triglycerides. So, anything that reduces cholesterol and reduces triglycerides is going to reduce ApoB. Triglycerides are generally driven by carbohydrate intake. So, more insulin resistance, mor...
摘要: Background The nonHDLc/HDLc ratio (in which nonHDLc is defined as total cholesterol minus HDLc) is positively associated with multiple dyslipidemia-related disorders. This study aimed to determine...关键词: nonHDLc/HDLc ratio, Incidence, Non-alcoholic fatty liver disease, Prospective study ...
[2] A test measuring it shows the concentration of all such particles, including LDL cholesterol and other markers like: Very low-density lipoproteins (VLDL) Intermediate-density lipoproteins (IDL) Chylomicrons Apolipoprotein A These particles usually harmlessly pass through arteries but can sometim...
Rather, non-HDL-C appears to be an indirect way of estimating apoB. We argue that we should integrate the information from non-HDL-C and apoB for better risk assessment and a better target of therapy. 展开 关键词: apoB Cardiovascular disease Non-HDL–C Risk factors VLDL-C ...
In comparison, VLDL did not stimulate effective cellular eGFP expression using a similar range of particle numbers. The corona composition was determined for samples equivalent to the 100 ng/well dose (Fig. 6b). Remarkably, HDL and VLDL could both contribute ApoE to LNPcor, but otherwise the...