TNFa, a pro-inflammatory cytokine, is known to be involved in the pathogenesis of allergic asthma. In DRG neurons, the hyperalgesic action of TNFa is mediated in part by upregulation of TRPV1-mediated responses. This study was carried out to test whether TNFa increases TRPV1 sensitivity in...
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid meta...
Typical depressive patterns were observed in in vivo studies in which healthy participants were given endotoxin infusions to trigger cytokine release, something similar seen in many patients who received interferon to treat hepatitis C [53,54,55]. Exacerbated inflammatory responses have often been observ...
TNFα treatment induced cytokine expression in BxPC-3 cells. Treatment of BxPC-3 cells (black box, bottom left panel) with TNFα stimulated TNFA mRNA synthesis compared with the PRNP null BxPC-3-PrP−/− cells (open box, bottom left panel). TNFα treatment induced the production of ...
Growth inhibition of Lin-Sca-I+c-kit+ HSCs from wild- typemiceby TNFa in a single-cell proliferation assay. A single-cell proliferation assay was performed to exclude the possibility of indirect effects of TNFa. mTNFa inhibited the proliferation of L-3plus SCF-induced Lin-Sca-l+c-kit+ ...
(multipleOAS,GBP, andIFItype genes)43,44,45. Apoptosis pathway genes included both pro- (TNF,LTB,GZMB,TNFRSF9) and anti- (BCL2A1,BIRC3,NFKB1,NKB2,NFKBIA,TNFRSF6B,TNFAIP3,TNFAIP8,TNFRSF11B,PTGS2,IFI6) apoptotic factors. Cytokine and chemokine signaling pathways were comprised of ...
Akkermansia, and Turicibacter, while Muribaculum, Anaeroplasma, Candidatus Arthromitus, and Candidatus Saccharimonas displayed an inverse relationship. Repression of TGFb and STAT3, and the concomitant elevation of TNFa, IFNg, and CXCR4 expression, ultimately underscored the observed enhancement in anti-ca...
Introduction The pleiotropic cytokine tumor necrosis factor alpha (TNF␣) exerts biological activity in CNS (1–4). TNF␣ effects in brain parenchyma are shown to play a key role in brain injury (5–8). High TNF␣ levels have been detected in brain Address correspondence and reprint ...
(HPF) were counted in six sections from four independent mice from each group. Data is presented as the mean ± SEM per HPF.iThe expression of proinflammatory cytokine genes includingIl-1,Cxcl1,Cxcl2,Tnfa,andCcl2examined by real-time PCR,n = 7.j,kH&E and PAS/Alcian blue ...
TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis Rodriguez-Rodriguez,L.,Gonzalez-Juanatey,... - 《Atherosclerosis Amsterdam》 被引量: 166发表: 2011年 A study of TNF-alpha-238 and -308 polymorphisms with different...