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microRNAVitiligoTo conduct a clinical biochemical study that aids in investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, MALAT-1 and miR-9 in attempt to provide new diagnostic biomarkers in vitiligo patients for Egyptians. Twenty ...
Initially, we measured cell viability after transcript knock-down using two different cell lines that overexpressed the lncRNA candidates (Fig. 2c, d). Of note, viability was reduced in all cell lines depleted of CTD-2015G9, RP11-19E11.1, or RP3-522D1.1, but there was no effect ...
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems1. Although key features are conserved across evolution2, eukaryotes...
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In this study, we evaluated the effect of TLR7 and NOD2 agonists. TLR7 recognizes viral single-stranded RNA. Its stimulation induces the secretion of pro-inflammatory cytokines and type I IFN. The stimulation of this receptor is known to induce CD4+ and CD8+ T cell responses in vivo [8,9...
Rather than there being a single regulatory event that governs the activities of all downstream sex determination regulatory genes-turning on Sex lethal (Sxl) RNA splicing activity in females while leaving it turned off in males-there are, in addition, elaborate temporal and spatial transcriptional ...
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